Evaluation of Lsa46 and Lsa77 Leptospiral Proteins for Their Immunoprotective Activities in Hamster Model of Leptospirosis

Table 2

Effect of immunization with Lsa46 recombinant protein in a hamster model.

Groups	N° Survivors /		N°Survivors/Total	Total	Renal	Renal	Renal
	Total			Survival	Culture	Culture	Culture	Culture
								Positive
					Positive /	Positive /	Positive /
					Total	Total	Total
	Exp.1	Exp. 2			Exp. 1	Exp. 2
PBS	0/6	2/10	2/16	13	-	2/2	2/2	100
Bacterin	6/6	10/10	16/16	100	0/6	0/10	0/16	0
Lsa46 +	4/6	3/10	7/16	44	3/4	3/3	6/7	85
Alum
p-value	0,03	0,5	0,056

The statistical analysis refers to Fisher’s exact test.p-values <0,05 were considered statistically significant.