Research Article
Evaluation of Lsa46 and Lsa77 Leptospiral Proteins for Their Immunoprotective Activities in Hamster Model of Leptospirosis
Table 2
Effect of immunization with Lsa46 recombinant protein in a hamster model.
| Groups | N° Survivors / | N°Survivors/Total | Total | Renal | Renal | Renal | | | Total | | Survival | Culture | Culture | Culture | Culture | | | | | | | | | Positive |
| | | | | | Positive / | Positive / | Positive / | | | | | | | Total | Total | Total | |
| | Exp.1 | Exp. 2 | | | Exp. 1 | Exp. 2 | | |
| PBS | 0/6 | 2/10 | 2/16 | 13 | - | 2/2 | 2/2 | 100 |
| Bacterin | 6/6 | 10/10 | 16/16 | 100 | 0/6 | 0/10 | 0/16 | 0 |
| Lsa46 + | 4/6 | 3/10 | 7/16 | 44 | 3/4 | 3/3 | 6/7 | 85 | Alum | | | | | | | | |
| p-value | 0,03 | 0,5 | 0,056 | | | | | |
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The statistical analysis refers to Fisher’s exact test. p-values <0,05 were considered statistically significant. |