Research Article
Evaluation of Lsa46 and Lsa77 Leptospiral Proteins for Their Immunoprotective Activities in Hamster Model of Leptospirosis
Table 4
Effect of immunization with Lsa46+Lsa77 recombinant proteins in a hamster model.
| Groups | N° Survivors/ | N°Survivors/ | Total | Renal | Renal | Renal | | | Total | Total | | Culture | Culture | Culture | Culture | | | | | | | | Positive |
| | | | | Survival | Positive / | Positive / | Positive / | | | | | | | Total | Total | Total | |
| | Exp. 1 | Exp. 2 | | | Exp. 1 | Exp. 2 | | |
| PBS | 4/6 | 3/6 | 7/12 | 58 | 2/4 | 3/3 | 5/7 | 71 |
| Bacterin | 6/6 | 6/6 | 12/12 | 100 | 0/6 | 0/6 | 0/12 | 0 |
| Lsa46 + | 6/6 | 5/6 | 11/12 | 90 | 2/6 | 3/5 | 5/11 | 45 | Lsa77 / | | | | | | | | | Alum | | | | | | | | |
| p-value | 0,22 | 0,27 | 0,07 | | | | | |
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The statistical analysis refers to Fisher’s exact test. p-values <0,05 were considered statistically significant. |