Evaluation of Lsa46 and Lsa77 Leptospiral Proteins for Their Immunoprotective Activities in Hamster Model of Leptospirosis

Table 4

Effect of immunization with Lsa46+Lsa77 recombinant proteins in a hamster model.

Groups	N° Survivors/		N°Survivors/	Total	Renal	Renal	Renal
	Total		Total		Culture	Culture	Culture	Culture
								Positive
				Survival	Positive /	Positive /	Positive /
					Total	Total	Total
	Exp. 1	Exp. 2			Exp. 1	Exp. 2
PBS	4/6	3/6	7/12	58	2/4	3/3	5/7	71
Bacterin	6/6	6/6	12/12	100	0/6	0/6	0/12	0
Lsa46 +	6/6	5/6	11/12	90	2/6	3/5	5/11	45
Lsa77 /
Alum
p-value	0,22	0,27	0,07

The statistical analysis refers to Fisher’s exact test.p-values <0,05 were considered statistically significant.