Analysis of In Vitro Cyto- and Genotoxicity of Barbatimão Extract on Human Keratinocytes and Fibroblasts

Figure 4

Comparison among genotoxic and apoptotic markers of keratinocytes and fibroblasts exposed to barbatimão hydroalcoholic extraction. (a) 8-OHdG levels; (b) BAX/Bcl-2 gene expression ratio quantified by qRT-PCR, that indicates modulation of intrinsic apoptotic events; (c) caspase 3 protein levels; (d) caspase 8 protein levels. Data were compared by one-way analysis of variance (ANOVA) followed by a Tukey post hoc test. In each marker tested here, statistical differences at p ≤ 0.05 among 24 h cell cultures treatments were identified by different letters (A, B, C).

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