Human Papillomavirus 16 Oncoproteins Downregulate the Expression of miR-148a-3p, miR-190a-5p, and miR-199b-5p in Cervical Cancer
Table 1
Characteristics of the clinical cervical tissue samples.
Related experiment
Group
Sample type
No. Sample
HPV genotype
Bethesda system & FIGO stage (N)
Hybridization
HPV16-negative normal (NN) cervix
FFPE
3
Not detected
-
HPV16-negative cervical carcinoma (NC)
FFPE
3
Not detected
CIN II (1), CIN III (2)
Hybridization & 1st qPCR
HPV16-positive normal (PN) cervix
FFPE
1
16
-
2
16 & other
-
HPV16-positive cervical carcinoma (PC)
FFPE
3
16
CIN III (1), IA1 (2)
2nd qPCR
HPV16-positive normal (PN) cervix
FFPE
2
16
-
2
16 & other
-
HPV16-positive cervical carcinoma (PC)
FFPE
8
16
IA1 (1), 1B1 (1), IB2 (1), IIA (1), IIB (4)
2
16 & other
IA1 (1), 1B1 (1)
Frozen
9
16
IB2 (5), IIA (2), IIB (1), III (1)
3
16 & 18
1B1 (1), IB2 (1), IIA (1)
3
16 & other
IB2 (2), IIA (1)
HPV genotyping resulted in four categories: not detected, only HPV16 detected (16), co-infected with HPV16 and HPV18 (16 & 18), and co-infected with HPV16 and high-risk viruses other than HPV16 and HPV18 (16 & other). Abbreviations: CIN, cervical intraepithelial neoplasia; FFPE, formalin-fixed paraffin-embedded; FIGO, international federation of gynecology and obstetrics; HPV, human papilloma virus; qPCR, quantitative PCR.
