Human Papillomavirus 16 Oncoproteins Downregulate the Expression of miR-148a-3p, miR-190a-5p, and miR-199b-5p in Cervical Cancer
Table 2
The relative expression fold of selected miRNAs with different FIGO stage.
FIGO stage
miR-148a-3p
miR-199b-5p
miR-190a-5p
miR-655-3p
(I) Compared with U6
P value
P value
P value
P value
PN (control)
282.20
225.89
7.50
1.68
IA
205.27
0.0385
62.03
0.0125
3.55
0.0075
0.51
0.0053
IB
188.13
0.5729
23.88
<0.0001
2.10
0.0006
0.28
0.0157
IIA
156.64
0.0003
27.69
<0.0001
2.13
<0.0001
0.28
<0.0001
IIB and III
102.17
<0.0001
16.59
<0.0001
2.61
<0.0001
0.21
<0.0001
(II) Compared with control
P value
P value
P value
P value
IA
0.73
0.0009
0.27
0.0001
0.47
0.0001
0.30
<0.0001
IB
0.67
0.4128
0.11
0.0001
0.28
<0.0001
0.17
0.0056
IIA
0.56
<0.0001
0.12
0.0001
0.28
<0.0001
0.17
<0.0001
IIB and III
0.36
<0.0001
0.07
<0.0001
0.35
<0.0001
0.12
<0.0001
= Target Cт – RNU6 Cт, = Normalized target gene amount relative to RUN6 gene amount of each group (multiplied by 1000). = Target sample - control sample , = Normalized gene amount of target group relative to target gene amount of control group. Abbreviations: FIGO, international federation of gynecology and obstetrics; PN, HPV16-positive normal.
