Integrated Analysis of MicroRNA (miRNA) and mRNA Profiles Reveals Reduced Correlation between MicroRNA and Target Gene in Cancer

Figure 1

Flowchart of this coexpression correlation analysis for miRNA-target gene pairs. Totally 5680 RNA and 5740 miRNA sequencing samples across 11 human cancers from TCGA were included. Among these samples, 5650 samples with both miRNA and mRNA expression data were used for coexpression correlation analysis. Further, 476 patients, who donated their tumor tissues and adjacent nontumor tissues, were used to confirm the results.