Integrated Analysis of MicroRNA (miRNA) and mRNA Profiles Reveals Reduced Correlation between MicroRNA and Target Gene in Cancer

Figure 4

The distribution of Pearson correlation coefficients of critical miRNA-target gene pairs in paired normal and tumor samples. The number next to the cancer type is the total number of critical pairs and the number next to clinical status symbol is the sample size of this group. The pairs were divided into two groups according gene’s up-(red) or down-(cyan) regulated status. The pan-cancer box plots include Pearson correlation coefficient values for normal and tumor belonging to the 11 cancer types.