Integrated Analysis of MicroRNA (miRNA) and mRNA Profiles Reveals Reduced Correlation between MicroRNA and Target Gene in Cancer

Table 2

The most common critical miRNA-target gene pairs in 11 cancer types.

Critical pairs	BLCA	BRCA	HNSC	KICH	KIRC	KIRP	LIHC	LUAD	LUSC	STAD	THCA	Frequency
miR-183/NEGR1	0.64	0.50	/	0.31	/	0.18	/	/	/	0.50	0.25	6
miR-210/SCN7A	0.16	-0.37	0.20	/	0.31	0.49	/	/	/	0.00	/	6
miR-21/EPM2A	/	0.34	0.65	/	0.23	0.30	0.03	/	/	0.49	/	6
miR-21/LIFR	0.42	0.47	0.62	/	/	0.32	/	/	/	/	-0.05	5
miR-182/PCOLCE2	0.51	0.30	/	0.68	/	0.42	/	/	/	0.30	/	5
miR-21/FAXDC2	/	0.57	0.74	/	/	/	0.04	/	/	0.47	-0.32	5
miR-21/SOX5	0.16	0.66	/	/	/	/	/	/	/	0.24	0.43	4
miR-183/AKAP12	0.40	0.43	/	/	/	/	/	/	/	0.77	0.05	4
miR-195/CCNE1	0.16	-0.13	0.08	/	/	/	/	0.25	/	/	/	4
miR-96/RECK	0.63	0.23	0.45	/	/	/	/	/	/	0.19	/	4

Note: The value equals Pearson correlation coefficient value in tumor group minus Pearson correlation coefficient value in normal group. Larger value means greater difference of correlation for the miRNA-target gene pairs in the tumor tissues relative to normal tissues. ‘/’ denotes absence of this pair in this cancer type.