Integrated Analysis of MicroRNA (miRNA) and mRNA Profiles Reveals Reduced Correlation between MicroRNA and Target Gene in Cancer
Table 3
The top two miRNA-target gene pairs in healthy controls.
Critical pairs
Cancer
r_hc (p-value)
r_early (p-value)
r_advanced (p-value)
miR-429/KLHL42
BLCA
-0.91(5.34E-08)
-0.20(2.11E-02)
-0.16(8.89E-03)
miR-200c/KLHL42
BLCA
-0.91(5.74E-08)
-0.22(1.28E-02)
-0.14(2.00E-02)
miR-200a/HHIP
BRCA
-0.80(2.74E-24)
-0.09(1.68E-02)
0.04(4.75E-01)
miR-200b/HHIP
BRCA
-0.80(3.34E-24)
-0.08(2.46E-02)
0.02(7.42E-01)
miR-30a/CDC20
HNSC
-0.80(8.01E-11)
-0.17(1.09E-01)
-0.02(7.76E-01)
miR-30a/KPNA2
HNSC
-0.80(8.75E-11)
-0.21(3.97E-02)
-0.15(7.20E-03)
miR-369/TRIM2
KICH
-0.80(2.26E-06)
-0.25(9.14E-02)
-0.62(3.60E-03)
miR-127/TMEM116
KICH
-0.79(4.63E-06)
-0.21(1.64E-01)
-0.66(1.69E-03)
miR-203a/PDE7A
KIRC
-0.83(7.19E-19)
-0.02(7.12E-01)
0.06(3.61E-01)
miR-203a/SPATA18
KIRC
-0.82(1.54E-18)
0.01(8.50E-01)
0.11(1.24E-01)
miR-31/SLC16A9
KIRP
-0.85(7.81E-10)
0.20(5.96E-03)
0.06(6.26E-01)
miR-589/FGF1
KIRP
-0.85(1.01E-09)
-0.16(2.42E-02)
0.04(6.26E-01)
miR-21/EPM2A
LIHC
-0.67(9.03E-08)
-0.45(8.85E-14)
-0.24(2.07E-02)
miR-21/GNE
LIHC
-0.67(1.06E-07)
-0.24(9.07E-05)
-0.24(2.51E-02)
miR-493/AGTPBP1
LUAD
-0.75(1.49E-04)
-0.17(5.89E-04)
-0.17(8.77E-02)
let-7d/CLDN12
LUAD
-0.72(2.99E-04)
0.04(4.07E-01)
0.08(4.18E-01)
miR-30d/MYBL2
LUSC
-0.68(3.19E-06)
-0.22(1.96E-05)
-0.10(3.71E-01)
miR-30b/CELSR3
LUSC
-0.67(3.49E-06)
0.06(2.32E-01)
0.06(6.15E-01)
miR-200a/TCF7L1
STAD
-0.89(1.06E-11)
-0.59(8.29E-17)
-0.42(2.71E-09)
miR-183/NEGR1
STAD
-0.89(1.11E-11)
-0.59(1.96E-16)
-0.50(5.31E-13)
miR-221/PRDM16
THCA
-0.72(2.56E-10)
-0.41(5.85E-15)
-0.41(3.41E-08)
miR-221/ASXL3
THCA
-0.71(3.01E-10)
-0.50(9.48E-23)
-0.53(2.19E-13)
Note: Pearson correlation coefficients and its adjusted p-value are listed. These miRNA-target gene pairs showed stronger correlation in healthy controls than in early stage and advanced stage tumors.
