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BioMed Research International
Volume 2018, Article ID 1984879, 11 pages
Review Article

Current Methods for Skeletal Muscle Tissue Repair and Regeneration

1Clinic for Trauma Surgery, Orthopedics and Plastic Surgery, University Medical Center Göttingen, Göttingen, Germany
2Clinic for Plastic Surgery, Technische Universität München, München, Germany
3Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Correspondence should be addressed to Arndt F. Schilling; ed.negnitteog-inu.dem@gnillihcs.tdnra

Received 27 October 2017; Revised 28 February 2018; Accepted 11 March 2018; Published 16 April 2018

Academic Editor: Cho-Pei Jiang

Copyright © 2018 Juan Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Skeletal muscle has the capacity of regeneration after injury. However, for large volumes of muscle loss, this regeneration needs interventional support. Consequently, muscle injury provides an ongoing reconstructive and regenerative challenge in clinical work. To promote muscle repair and regeneration, different strategies have been developed within the last century and especially during the last few decades, including surgical techniques, physical therapy, biomaterials, and muscular tissue engineering as well as cell therapy. Still, there is a great need to develop new methods and materials, which promote skeletal muscle repair and functional regeneration. In this review, we give a comprehensive overview over the epidemiology of muscle tissue loss, highlight current strategies in clinical treatment, and discuss novel methods for muscle regeneration and challenges for their future clinical translation.