PATRI, a Genomics Data Integration Tool for Biomarker Discovery

Figure 2

PATRI analysis workflows. Schematic representation of the PATRI tool analysis workflows. (a) “Translational” workflow (black arrows), executing a statistical identification of candidate baseline genomics biomarkers starting from defined treatment “Sensitive” versus “Resistant” cell line groups, through categorization of “biomarker sensitive” versus “biomarker resistant” clinical samples in the annotated clinical dataset, based on the selected gene candidates, with simultaneous identification of statistically correlated differentiating characteristics. (b) “Clinical” workflow (white arrows), executing the same operations as in the “Translational” workflow, starting from defined treatment “Sensitive” (responder) versus “Resistant” (nonresponder) tumor samples in pretreatment clinical genomics datasets.