Research Article

In Vitro Cytotoxicity and In Vivo Antimammary Tumor Effects of the Hydroethanolic Extract of Acacia seyal (Mimosaceae) Stem Bark

Table 4

Effects of A. seyal extract on relative weight of various organs after 20 weeks of treatment.

OrgansNORDMBATamox + DMBAAS 50 + DMBAAS 150 + DMBAAS 300 + DMBA

Uterus
Liver
Lungs
Spleen
Adrenals
Kidneys
Femur
Brain
Ovaries

NOR = normal control treated with 2% ethanol; DMBA = DMBA control treated with water; AS + DMBA = animals treated with the Acacia seyal hydroethanolic extract at the doses of 50, 150 and 300 mg/kg. TAM + DMBA = animals treated with tamoxifen (3.3 mg/kg); all groups excepting the normal group (NOR) received an intragastric dose of DMBA at the dose of 80 mg/kg. Data are represented as mean ± SEM (). , and as compared to negative control; and as compared to normal control.