In Vitro Cytotoxicity and In Vivo Antimammary Tumor Effects of the Hydroethanolic Extract of Acacia seyal (Mimosaceae) Stem Bark

Table 5

Effects of A. seyal hydroethanolic extract on some toxicological biochemical parameters after 20 weeks of treatment.

Item	NOR	DMBA	TAM + DMBA	AS 50 + DMBA	AS 150 + DMBA	AS 300 + DMBA
Transaminases
ALT
AST
Fasting Lipid levels
Total cholesterol (g/L)
TG (mg/dL)
Chol-HDL (g/L)
Chol-LDL (g/L)
Chol-T/Chol-HDL
log10 (TG/Chol-HDL)
Creatine (g/L)	1,12 ± 0,03	1,05 ± 0,1	1,41 ± 0,07	1,13 ± 0,04	1,08 ± 0,06	1,13 ± 0,04

NOR = normal control treated with water; DMBA = DMBA control treated with 2% ethanol; TAM + DMBA = positive control treated with tamoxifen (3.3 mg/kg); AS + DMBA = animals treated with the A. seyal extract (v/v: 1/1) at the doses of 50, 150, and 300 mg/kg. All groups except of normal group (NOR) received an intragastric dose of DMBA at the dose of 80 m/kg. Data are represented as mean ± SEM (). , and as compared to negative control; as compared to normal control.