F806 Suppresses the Invasion and Metastasis of Esophageal Squamous Cell Carcinoma via Downregulating F-Actin Assembly-Related Rho Family Proteins

Figure 2

F806 suppresses the invasion and metastasis of ESCC cells in vivo. (a) The regional lymph node metastasis models of ESCC xenograft. (b) The growth curves of tumor volume were plotted in control and treated groups of xenograft models. (c) The volume percentage of tumors from the xenograft models in control and F806-treated mice. (d) Representative hematoxylin-eosin staining of lymph node metastasis sections from the inguinal regions. (e) The lymph node metastasis ratio from the inguinal regions. Scale bar = 50 μm. Data are mean ± SD, P < 0.05; P<0.01; P<0.001, compared to the control group; n=7. F-4: 4 mg/kg F806; F-8: 8 mg/kg F806.

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