lncRNA-MEG3 Suppresses the Proliferation and Invasion of Melanoma by Regulating CYLD Expression Mediated by Sponging miR-499-5p

Figure 1

The levels of MEG3, miR-499-5p, and CYLD in melanoma samples and cell lines. (a) The MEG3 expression was reduced markedly in 42 melanoma samples in comparison with paired normal samples. (b) Reduced expression of MEG3 was found in melanoma cell lines in comparison with normal skin melanocytes (HEMa-LP). (c) The expression of miR-499-5p in melanoma cell lines was distinctly higher, respectively, than in normal human melanocytes (HEMa-LP). (d) The level of miR-499-5p was greatly overexpressed in tumor tissue samples in comparison with nontumor samples. (e and f) The CYLD level was decreased markedly in tumor samples in comparison with nontumor samples. (g) The CYLD expression in melanoma cell lines was considerably lower than in normal human melanocytes (HEMa-LP). ( compared with nontumor tissues group. compared with HEMa-LP group.)

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