lncRNA-MEG3 Suppresses the Proliferation and Invasion of Melanoma by Regulating CYLD Expression Mediated by Sponging miR-499-5p

Figure 9

MEG3 inhibited the growth and invasion of A375 cells by regulating the expression of CYLD. (a) Downregulation of MEG3 enhanced the growth, cell cycle, and invasion of A375 cells and suppressed the apoptosis of A375 cells compared with sh-control group. Besides, forced expression of CYLD attenuated the promoting function of sh-MEG3 in the growth, cell cycle, and invasion of A375 cells and the suppressing function of sh-MEG3 in the apoptosis of A375 cells. (b) Upregulation of MEG3 attenuated the proliferation, cell cycle, and invasion of A375 cells and promoted A375 cells apoptosis compared with pcDNA-control group. In addition, reduced expression of CYLD enhanced the proliferation, cell cycle, and invasion of A375 cells transfected with pcDNA-MEG3 and reduced the apoptosis of A375 cells transfected with pcDNA-MEG3. ( compared with sh-control group. compared with sh-MEG3 group. compared with pcDNA-control group. compared with pcDNA-MEG3 group.)

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