Plasma Chemokine CCL2 and Its Receptor CCR2 Concentrations as Diagnostic Biomarkers for Breast Cancer Patients

Table 4

Diagnostic criteria of ROC curve for tested parameters and CA 15-3.

Tested parameters	AUC	SE	95% C.I. (AUC)	p (AUC=0.5)
	ROC criteria in breast cancer (total group)
CCL2	0.7154	0.0410	0.635-0.796	<0.001
CCR2	0.7304	0.0412	0.650-0.811	<0.001
CA 15-3	0.7354	0.0389	0.659-0.812	<0.001
CCL2+ CA 15-3	0.7771	0.0363	0.706-0.848	<0.001
CCR2+ CA 15-3	0.7879	0.0349	0.719-0.856	<0.001
CCL2+ CCR2+ CA 15-3	0.8271	0.0316	0.765-0.889	<0.001
	ROC criteria in breast cancer (I stage)
CCL2	0.6604	0.0620	0.539-0.782	0.0097
CCR2	0.6564	0.0584	0.542-0.771	0.0074
CA 15-3	0.6452	0.0655	0.517-0.774	0.0266
CCL2+ CA 15-3	0.6783	0.0620	0.557-0.800	0.0040
CCR2+ CA 15-3	0.7031	0.0606	0.584-0.822	<0.001
CCL2+ CCR2+ CA 15-3	0.7367	0.0575	0.624-0.849	<0.001
	ROC criteria in breast cancer (II stage)
CCL2	0.6615	0.0625	0.539-0.784	0.0097
CCR2	0.7768	0.0479	0.683-0.871	<0.001
CA 15-3	0.7163	0.0551	0.608-0.824	<0.001
CCL2+ CA 15-3	0.7575	0.0541	0.652-0.863	<0.001
CCR2+ CA 15-3	0.7940	0.0448	0.706-0.882	<0.001
CCL2+ CCR2+ CA 15-3	0.8317	0.0416	0.750-0.913	<0.001
	ROC criteria in breast cancer (III and IV stages)
CCL2	0.8983	0.0417	0.817-0.980	<0.001
CCR2	0.7605	0.0570	0.649-0.872	<0.001
CA 15-3	0.9098	0.0426	0.826-0.993	<0.001
CCL2+ CA 15-3	0.9654	0.0184	0.929-1.001	<0.001
CCR2+ CA 15-3	0.9076	0.0437	0.822-0.993	<0.001
CCL2+ CCR2+ CA 15-3	0.9582	0.0248	0.909-1.007	<0.001

p: statistically significantly larger AUC compared to AUC=0.5.