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BioMed Research International
Volume 2018, Article ID 2176056, 8 pages
https://doi.org/10.1155/2018/2176056
Review Article

Treatment of Elderly Patients with Colorectal Cancer

Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan

Correspondence should be addressed to Kenji Kawada; pj.ca.u-otoyk.phuk@adawakk

Received 24 August 2017; Accepted 11 February 2018; Published 11 March 2018

Academic Editor: Meritxell Arenas

Copyright © 2018 Yoshiro Itatani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. As society ages, the number of elderly patients with CRC will increase. The percentage of patients with right-sided colon cancer and the incidence of microsatellite instability are higher in elderly than in younger patients with CRC. Moreover, the higher incidence of comorbid diseases in elderly patients indicates the need for less invasive treatment strategies. For example, care should be taken in performing additional surgery after endoscopic submucosal dissection for elderly patients with high-risk T1 CRC. Minimally invasive surgery, such as laparoscopic colectomy, would be preferable for elderly patients with CRC. Chemotherapy for elderly patients requires careful monitoring for adverse events. The aim of this review is to summarize the clinicopathological features of CRC in elderly patients, optical surgical strategies, including endoscopic and laparoscopic resection, and chemotherapeutic strategies, including postoperative adjuvant chemotherapy and systemic chemotherapy for unresectable CRC.