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BioMed Research International
Volume 2018, Article ID 2176056, 8 pages
https://doi.org/10.1155/2018/2176056
Review Article

Treatment of Elderly Patients with Colorectal Cancer

Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan

Correspondence should be addressed to Kenji Kawada; pj.ca.u-otoyk.phuk@adawakk

Received 24 August 2017; Accepted 11 February 2018; Published 11 March 2018

Academic Editor: Meritxell Arenas

Copyright © 2018 Yoshiro Itatani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. (UNFPA), U.N.P.F., http://www.unfpa.org/ageing.
  2. M. Malvezzi, P. Bertuccio, F. Levi, C. La Vecchia, and E. Negri, “European cancer mortality predictions for the year 2014,” Annals of Oncology, vol. 25, no. 8, pp. 1650–1656, 2014. View at Publisher · View at Google Scholar
  3. M. Hori, T. Matsuda, A. Shibata, K. Katanoda, T. Sobue, and H. Nishimoto, “Cancer incidence and incidence rates in Japan in 2009: a study of 32 population-based cancer registries for the Monitoring of Cancer Incidence in Japan (MCIJ) project,” Japanese Journal of Clinical Oncology, vol. 45, no. 9, pp. 884–891, 2015. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Jemal, E. M. Ward, C. J. Johnson et al., “Annual Report to the Nation on the Status of Cancer, 1975-2014, Featuring Survival,” Journal of the National Cancer Institute, vol. 109, no. 9, Article ID djx030, 2017. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Arnold, M. S. Sierra, M. Laversanne, I. Soerjomataram, A. Jemal, and F. Bray, “Global patterns and trends in colorectal cancer incidence and mortality,” Gut, vol. 66, no. 4, p. 683, 2017. View at Publisher · View at Google Scholar · View at Scopus
  6. “Common Toxicity Criteria (CTC),” http://ecog-acrin.org/resources/ecog-performance-status.
  7. P. Alley, “Surgery for colorectal cancer in elderly patients: a systematic review,” The Lancet, vol. 356, no. 9234, pp. 956–974, 2000. View at Publisher · View at Google Scholar
  8. F. E. Turrentine, H. Wang, V. B. Simpson, and R. S. Jones, “Surgical Risk Factors, Morbidity, and Mortality in Elderly Patients,” Journal of the American College of Surgeons, vol. 203, no. 6, pp. 865–877, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. M. D. Jafari, F. Jafari, W. J. Halabi et al., “Colorectal cancer resections in the aging US population: A trend toward decreasing rates and improved outcomes,” JAMA Surgery, vol. 149, no. 6, pp. 557–564, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. K. Kotake, M. Asano, H. Ozawa, H. Kobayashi, and K. Sugihara, “Tumour characteristics, treatment patterns and survival of patients aged 80 years or older with colorectal cancer,” Colorectal Disease, vol. 17, no. 3, pp. 205–215, 2015. View at Publisher · View at Google Scholar · View at Scopus
  11. R. L. Siegel, K. D. Miller, S. A. Fedewa et al., “Colorectal cancer statistics,” CA: A Cancer Journal for Clinicians, vol. 67, no. 3, pp. 177–193, 2017. View at Publisher · View at Google Scholar · View at Scopus
  12. T. Aparicio, O. Schischmanoff, C. Poupardin et al., “Deficient mismatch repair phenotype is a prognostic factor for colorectal cancer in elderly patients,” Digestive and Liver Disease, vol. 45, no. 3, pp. 245–250, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Kakar, L. J. Burgart, S. N. Thibodeau et al., “Frequency of loss of hMLH1 expression in colorectal carcinoma increases with advancing age,” Cancer, vol. 97, no. 6, pp. 1421–1427, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. M. F. Kane, M. Loda, G. M. Gaida et al., “Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines,” Cancer Research, vol. 57, no. 5, pp. 808–811, 1997. View at Google Scholar · View at Scopus
  15. S. R. Malkhosyan, H. Yamamoto, Z. Piao, and M. Perucho, “Late onset and high incidence of colon cancer of the mutator phenotype with hypermethylated hMLH1 gene in women [3],” Gastroenterology, vol. 119, no. 2, p. 598, 2000. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Akyol, T. Hinoi, Y. Feng, G. T. Bommer, T. M. Glaser, and E. R. Fearon, “Generating somatic mosaicism with a Cre recombinase-microsatellite sequence transgene,” Nature Methods, vol. 5, no. 3, pp. 231–233, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. S. N. Thibodeau, G. Bren, and D. Schaid, “Microsatellite instability in cancer of the proximal colon,” Science, vol. 260, no. 5109, pp. 816–819, 1993. View at Publisher · View at Google Scholar · View at Scopus
  18. P. Jernvall, M. J. Mäkinen, T. J. Karttunen, J. Mäkelä, and P. Vihko, “Microsatellite instability: Impact on cancer progression in proximal and distal colorectal cancers,” European Journal of Cancer, vol. 35, no. 2, pp. 197–201, 1999. View at Publisher · View at Google Scholar · View at Scopus
  19. T. Arai and K. Takubo, “Clinicopathological and molecular characteristics of gastric and colorectal carcinomas in the elderly,” Pathology International, vol. 57, no. 6, pp. 303–314, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. V. L. J. Whitehall and B. A. Leggett, “The serrated pathway of colorectal carcinogenesis,” Current Colorectal Cancer Reports, vol. 5, no. 2, pp. 75–83, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. J. R. Jass, V. L. J. Whitehall, J. Young, and B. A. Leggett, “Emerging concepts in colorectal neoplasia,” Gastroenterology, vol. 123, no. 3, pp. 862–876, 2002. View at Publisher · View at Google Scholar · View at Scopus
  22. B. Leggett and V. Whitehall, “Role of the Serrated Pathway in Colorectal Cancer Pathogenesis,” Gastroenterology, vol. 138, no. 6, pp. 2088–2100, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. J. R. Jass, “Classification of colorectal cancer based on correlation of clinical, morphological and molecular features,” Histopathology, vol. 50, no. 1, pp. 113–130, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Toyota, N. Ahuja, M. Ohe-Toyota, J. G. Herman, S. B. Baylin, and J. J. Issa, “CpG island methylator phenotype in colorectal cancer,” Proceedings of the National Acadamy of Sciences of the United States of America, vol. 96, no. 15, pp. 8681–8686, 1999. View at Publisher · View at Google Scholar · View at Scopus
  25. T. Arai, Y. Esaki, M. Sawabe, N. Honma, K.-I. Nakamura, and K. Takubo, “Hypermethylation of the hMLH1 promoter with absent hMLH1 expression in medullary-type poorly differentiated colorectal adenocarcinoma in the elderly,” Modern Pathology, vol. 17, no. 2, pp. 172–179, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. G. Lanza, R. Gafà, M. Matteuzzi, and A. Santini, “Medullary-type poorly differentiated adenocarcinoma of the large bowel: a distinct clinicopathologic entity characterized by microsatellite instability and improved survival,” Journal of Clinical Oncology, vol. 17, no. 8, pp. 2429–2438, 1999. View at Publisher · View at Google Scholar · View at Scopus
  27. D. M. Graham and H. D. Appelman, “Crohn's-like lymphoid reaction and colorectal carcinoma: a potential histologic prognosticator,” Modern Pathology, vol. 3, no. 3, pp. 332–335, 1990. View at Google Scholar
  28. N. Takemoto, F. Konishi, K. Yamashita et al., “The correlation of microsatellite instability and tumor-infiltrating lymphocytes in hereditary non-polyposis colorectal cancer (HNPCC) and sporadic colorectal cancers: The significance of different types of lymphocyte infiltration,” Japanese Journal of Clinical Oncology, vol. 34, no. 2, pp. 90–98, 2004. View at Publisher · View at Google Scholar · View at Scopus
  29. L. S. Rozek, S. L. Schmit, J. K. Greenson et al., “Tumor-Infiltrating lymphocytes, Crohn's-like lymphoid reaction, and survival from colorectal cancer,” Journal of the National Cancer Institute, vol. 108, no. 8, 2016. View at Publisher · View at Google Scholar · View at Scopus
  30. D. T. Le, Uram, H. Wang et al., “PD-1 Blockade in Tumors with Mismatch-Repair Deficiency,” The New England Journal of Medicine, vol. 372, no. 26, pp. 2509–2520, 2015. View at Google Scholar
  31. L. C. Cummings, C. P. Delaney, and G. S. Cooper, “Laparoscopic versus open colectomy for colon cancer in an older population: A cohort study,” World Journal of Surgical Oncology, vol. 10, article no. 31, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. T. Mukai, T. Akiyoshi, M. Ueno et al., “Outcomes of laparoscopic surgery for colorectal cancer in oldest-old patients,” Surgical Laparoscopy Endoscopy & Percutaneous Techniques, vol. 24, pp. 366–369, 2014. View at Google Scholar
  33. F. Vallribera Valls, F. Landi, E. Espín Basany et al., “Laparoscopy-assisted versus open colectomy for treatment of colon cancer in the elderly: morbidity and mortality outcomes in 545 patients,” Surgical Endoscopy, vol. 28, no. 12, pp. 3373–3378, 2014. View at Publisher · View at Google Scholar · View at Scopus
  34. T. Nakamura, T. Sato, H. Miura et al., “Feasibility and outcomes of surgical therapy in very elderly patients with colorectal cancer,” Surgical Laparoscopy Endoscopy & Percutaneous Techniques, vol. 24, no. 1, pp. 85–88, 2014. View at Publisher · View at Google Scholar · View at Scopus
  35. T. Hinoi, Y. Kawaguchi, M. Hattori et al., “Laparoscopic Versus Open Surgery for Colorectal Cancer in Elderly Patients: A Multicenter Matched Case–Control Study,” Annals of Surgical Oncology, vol. 22, no. 6, pp. 2040–2050, 2015. View at Publisher · View at Google Scholar · View at Scopus
  36. C. G. Moertel, T. R. Fleming, J. S. Macdonald et al., “Intergroup study of fluorouracil plus levamisole as adjuvant therapy for stage II/Dukes' B2 colon cancer,” Journal of Clinical Oncology, vol. 13, no. 12, pp. 2936–2943, 1995. View at Publisher · View at Google Scholar · View at Scopus
  37. G. Francini, R. Petrioli, L. Lorenzini et al., “Folinic acid and 5-fluorouracil as adjuvant chemotherapy in colon cancer,” Gastroenterology, vol. 106, no. 4, pp. 899–906, 1994. View at Publisher · View at Google Scholar · View at Scopus
  38. International Multicentre Pooled Analysis of Colon Cancer Trials (IMPACT) investigators, “Efficacy of adjuvant fluorouracil and folinic acid in colon cancer,” The Lancet, vol. 345, no. 8955, pp. 939–944, 1995. View at Publisher · View at Google Scholar · View at Scopus
  39. M. J. O'Connell, J. A. Mailliard, M. J. Kahn et al., “Controlled trial of fluorouracil and low-dose leucovorin given for 6 months as postoperative adjuvant therapy for colon cancer,” Journal of Clinical Oncology, vol. 15, no. 1, pp. 246–250, 1997. View at Publisher · View at Google Scholar · View at Scopus
  40. T. André, C. Boni, L. Mounedji-Boudiaf et al., “Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer,” The New England Journal of Medicine, vol. 350, no. 23, pp. 2343–2351, 2004. View at Publisher · View at Google Scholar · View at Scopus
  41. J. P. Kuebler et al., “Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: results from NSABP C-07,” Journal of Clinical Oncology, vol. 25, no. 16, pp. 2198–2204, 2007. View at Google Scholar
  42. T. André, C. Boni, M. Navarro et al., “Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial,” Journal of Clinical Oncology, vol. 27, no. 19, pp. 3109–3116, 2009. View at Publisher · View at Google Scholar · View at Scopus
  43. M. Fujishiro, N. Yahagi, N. Kakushima et al., “Outcomes of endoscopic submucosal dissection for colorectal epithelial neoplasms in 200 consecutive cases,” Clinical Gastroenterology and Hepatology, vol. 5, no. 6, pp. 678–683, 2007. View at Google Scholar
  44. N. Yoshida, Y. Naito, K. Sakai et al., “Outcome of endoscopic submucosal dissection for colorectal tumors in elderly people,” International Journal of Colorectal Disease, vol. 25, no. 4, pp. 455–461, 2010. View at Publisher · View at Google Scholar · View at Scopus
  45. Y. Takahashi, K.-I. Mizuno, K. Takahashi et al., “Long-term outcomes of colorectal endoscopic submucosal dissection in elderly patients,” International Journal of Colorectal Disease, vol. 32, no. 4, pp. 567–573, 2017. View at Publisher · View at Google Scholar · View at Scopus
  46. L. Liu, X. Shen, and J. Zhu, “Efficacy, Safety, and Overall Quality of Life of Endoscopic Submucosal Dissection for Early Colorectal Cancer in Elderly Patients,” Gastroenterology Research and Practice, vol. 2017, Article ID 2386291, 2017. View at Publisher · View at Google Scholar · View at Scopus
  47. T. Watanabe, K. Muro, Y. Ajioka et al., “Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2016 for the treatment of colorectal cancer,” International Journal of Clinical Oncology, 2017. View at Google Scholar
  48. H. Ueno, H. Mochizuki, Y. Hashiguchi et al., “Risk factors for an adverse outcome in early invasive colorectal carcinoma,” Gastroenterology, vol. 127, no. 2, pp. 385–394, 2004. View at Publisher · View at Google Scholar · View at Scopus
  49. J.-J. Duron, E. Duron, T. Dugue et al., “Risk factors for mortality in major digestive surgery in the elderly: A multicenter prospective study,” Annals of Surgery, vol. 254, no. 2, pp. 375–382, 2011. View at Publisher · View at Google Scholar · View at Scopus
  50. Clinical Outcomes of Surgical Therapy Study Group, “A comparison of laparoscopically assisted and open colectomy for colon cancer,” The New England Journal of Medicine, vol. 350, no. 20, pp. 2050–2059, 2004. View at Publisher · View at Google Scholar
  51. P. J. Guillou, P. Quirke, H. Thorpe et al., “Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial,” The Lancet, vol. 365, no. 9472, pp. 1718–1726, 2005. View at Publisher · View at Google Scholar · View at Scopus
  52. R. Veldkamp, E. Kuhry, W. C. Hop et al., “Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomised trial,” The Lancet Oncology, vol. 6, no. 7, pp. 477–484, 2005. View at Google Scholar
  53. D. G. Jayne, P. J. Guillou, H. Thorpe et al., “Randomized trial of laparoscopic-assisted resection of colorectal carcinoma: 3-Year results of the UK MRC CLASICC trial group,” Journal of Clinical Oncology, vol. 25, no. 21, pp. 3061–3068, 2007. View at Publisher · View at Google Scholar · View at Scopus
  54. M. Buunen, R. Veldkamp, and W. C. Hop, “Survival after laparoscopic surgery versus open surgery for colon cancer: long-term outcome of a randomised clinical trial,” The Lancet Oncology, vol. 10, no. 1, pp. 44–52, 2009. View at Publisher · View at Google Scholar
  55. A. K. Hemandas, T. Abdelrahman, K. G. Flashman et al., “Laparoscopic colorectal surgery produces better outcomes for high risk cancer patients compared to open surgery,” Annals of Surgery, vol. 252, no. 1, pp. 84–89, 2010. View at Publisher · View at Google Scholar · View at Scopus
  56. P. F. Bagshaw, R. A. Allardyce, C. M. Frampton et al., “Long-term outcomes of the australasian randomized clinical trial comparing laparoscopic and conventional open surgical treatments for colon cancer: The australasian laparoscopic colon cancer study trial,” Annals of Surgery, vol. 256, no. 6, pp. 915–919, 2012. View at Publisher · View at Google Scholar · View at Scopus
  57. M. M. Cone, D. O. Herzig, B. S. Diggs et al., “Dramatic decreases in mortality from laparoscopic colon resections based on data from the nationwide inpatient sample,” JAMA Surgery, vol. 146, no. 5, pp. 594–599, 2011. View at Publisher · View at Google Scholar · View at Scopus
  58. S. Webb, I. Rubinfeld, V. Velanovich, H. M. Horst, and C. Reickert, “Using national surgical quality improvement program (NSQIP) data for risk adjustment to compare Clavien 4 and 5 complications in open and laparoscopic colectomy,” Surgical Endoscopy, vol. 26, no. 3, pp. 732–737, 2012. View at Publisher · View at Google Scholar · View at Scopus
  59. A. J. Stefanou, C. A. Reickert, V. Velanovich, A. Falvo, and I. Rubinfeld, “Laparoscopic colectomy significantly decreases length of stay compared with open operation,” Surgical Endoscopy, vol. 26, no. 1, pp. 144–148, 2012. View at Publisher · View at Google Scholar · View at Scopus
  60. S. Vaid, J. Tucker, T. Bell, R. Grim, and V. Ahuja, “Cost analysis of laparoscopic versus open colectomy in patients with colon cancer: Results from a large nationwide population database,” The American Surgeon, vol. 78, no. 6, pp. 635–641, 2012. View at Google Scholar · View at Scopus
  61. H. Kuroyanagi, M. Inomata, Y. Saida et al., “Gastroenterological Surgery: Large intestine,” Asian Journal of Endoscopic Surgery, vol. 8, no. 3, pp. 246–262, 2015. View at Publisher · View at Google Scholar
  62. R. Okamura, K. Hida, S. Hasegawa et al., “Impact of intraoperative blood loss on morbidity and survival after radical surgery for colorectal cancer patients aged 80 years or older,” International Journal of Colorectal Disease, vol. 31, no. 2, pp. 327–334, 2016. View at Publisher · View at Google Scholar · View at Scopus
  63. L. Devoto, V. Celentano, R. Cohen, J. Khan, and M. Chand, “Colorectal cancer surgery in the very elderly patient: a systematic review of laparoscopic versus open colorectal resection,” International Journal of Colorectal Disease, vol. 32, no. 9, pp. 1237–1242, 2017. View at Publisher · View at Google Scholar · View at Scopus
  64. D. Superfin, A. A. Iannucci, and A. M. Davies, “Commentary: Oncologic drugs in patients with organ dysfunction: A summary,” The Oncologist, vol. 12, no. 9, pp. 1070–1083, 2007. View at Publisher · View at Google Scholar · View at Scopus
  65. T. Shiroyama, T. Kijima, K. Komuta et al., “Phase II tailored S-1 regimen study of first-line chemotherapy in elderly patients with advanced and recurrent non-small cell lung cancer,” Cancer Chemotherapy and Pharmacology, vol. 70, no. 6, pp. 783–789, 2012. View at Publisher · View at Google Scholar · View at Scopus
  66. E. Raymond, V. Boige, S. Faivre et al., “Dosage adjustment and pharmacokinetic profile of irinotecan in cancer patients with hepatic dysfunction,” Journal of Clinical Oncology, vol. 20, no. 21, pp. 4303–4312, 2002. View at Publisher · View at Google Scholar · View at Scopus
  67. S. Wu, C. Kim, L. Baer, and X. Zhu, “Bevacizumab increases risk for severe proteinuria in cancer patients,” Journal of the American Society of Nephrology, vol. 21, no. 8, pp. 1381–1389, 2010. View at Google Scholar
  68. C. G. Moertel, T. R. Fleming, J. S. Macdonald et al., “Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma,” The New England Journal of Medicine, vol. 322, no. 6, pp. 352–358, 1990. View at Google Scholar
  69. H. K. Sanoff, W. R. Carpenter, T. Sturmer et al., “Effect of adjuvant chemotherapy on survival of patients with stage III colon cancer diagnosed after age 75 years,” Journal of Clinical Oncology, vol. 30, no. 21, pp. 2624–2634, 2012. View at Publisher · View at Google Scholar
  70. T. J. Iwashyna and E. B. Lamont, “Effectiveness of adjuvant fluorouracil in clinical practice: A population-based cohort study of elderly patients with stage III colon cancer,” Journal of Clinical Oncology, vol. 20, no. 19, pp. 3992–3998, 2002. View at Publisher · View at Google Scholar · View at Scopus
  71. A. I. Neugut, M. Matasar, X. Wang et al., “Duration of adjuvant chemotherapy for colon cancer and survival among the elderly,” Journal of Clinical Oncology, vol. 24, no. 15, pp. 2368–2375, 2006. View at Publisher · View at Google Scholar · View at Scopus
  72. R. M. Goldberg, I. Tabah-Fisch, H. Bleiberg et al., “Pooled analysis of safety and efficacy of oxaliplatin plus fluorouracil/leucovorin administered bimonthly in elderly patients with colorectal cancer,” Journal of Clinical Oncology, vol. 24, no. 25, pp. 4085–4091, 2006. View at Publisher · View at Google Scholar · View at Scopus
  73. M. T. Seymour, L. C. Thompson, H. S. Wasan et al., “Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): An open-label, randomised factorial trial,” The Lancet, vol. 377, no. 9779, pp. 1749–1759, 2011. View at Publisher · View at Google Scholar · View at Scopus