Blood-Brain Barrier Damage as the Starting Point of Leukoaraiosis Caused by Cerebral Chronic Hypoperfusion and Its Involved Mechanisms: Effect of Agrin and Aquaporin-4

<div>Fiber densities being stained with Luxol fast blue in the deep white matter of the CCH rats (a) and quantitative fiber densities (b). From direct microscopical observations, LFB staining was slightly affected at 3 days (B), 1 week (C), and 2 weeks (D). At 1 and 3 months after 2VO (E, F), the fiber density was significantly decreased compared with that of the sham control (A). 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BioMed Research International

fig1

Figure 1

Figure 1: Blood-Brain Barrier Damage as the Starting Point of Leukoaraiosis Caused by Cerebral Chronic Hypoperfusion and Its Involved Mechanisms: Effect of Agrin and Aquaporin-4 

Figure 1 | Blood-Brain Barrier Damage as the Starting Point of Leukoaraiosis Caused by Cerebral Chronic Hypoperfusion and Its Involved Mechanisms: Effect of Agrin and Aquaporin-4 