High Expression of ITGA3 Promotes Proliferation and Cell Cycle Progression and Indicates Poor Prognosis in Intrahepatic Cholangiocarcinoma

Table 1

Correlation between ITGA3 expression and clinicopathological features of ICC patients.

Clinical parameter	ITGA3 expression		value
	High	Low
Age (years)
≥60	19	9	0.754
<60	13	5
Gender
Male	17	7	0.845
Female	15	7
HBV
Yes	7	3	1.000
No	25	11
AFP
≥20 µg/L	5	0	0.303
<20 µg/L	27	14
CA19-9
≥37 U/ml	26	11	1.000
<37 U/ml	6	3
Tumor size
≥6.5 cm	20	4	0.034
<6.5 cm	12	10
Tumor number
Single	17	10	0.246
Multiple	15	4
Lymph node metastasis
Yes	20	4	0.034
No	12	10
Liver cirrhosis
Yes	11	5	1.000
No	21	9
TNM stage
I-II	5	7	0.027
III-IV	27	5

Statistical analyses by Pearson’s test or Fisher’s exact test. Abbreviations. ICC: intrahepatic cholangiocarcinoma; ITGA3: integrin subunit alpha 3. Statistically significant values are boldfaced.