-Hederin Arrests Cell Cycle at G2/M Checkpoint and Promotes Mitochondrial Apoptosis by Blocking Nuclear Factor-B Signaling in Colon Cancer Cells

Figure 2

α-Hederin induces mitochondrial apoptosis in IL-6-stimulated SW620 cells. SW620 cells were treated with vehicle, IL-6, and/or α-hederin at indicated concentrations for 24 h. (a) Hoechst 33258 fluorescence staining. Morphologic changes of apoptotic cells were visualized under a fluorescence microscope (200 x magnification). (b) Flow cytometric analyses of MMP.

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