BRAF 1799T>A Mutation Frequency in Mexican Mestizo Patients with Papillary Thyroid Cancer

Table 1

Frequency of the BRAF 1799T>A mutation in the included thyroid tissue samples.

Diagnostic group	Number of samples	Mutation-positive samples	valu	OR (CI)
PTC	54	33 (61.1%)	-	-
CG	39	1 (2.5%)	7.2 × 10^−10	59.7 (7.6–468)
FA	11	1 (9.1%)	0.0016	15.7 (1.8–131)
Total benign	50	2 (4.0%)	1 × 10^−10	37.7 (8.2–171)
HT-PTC	43	3 (6.95%)	1.3 × 10^−8	NA

Samples correspond to histologically diagnosed papillary thyroid cancer (PTC), colloid goiter (CG), follicular adenoma (FA), and healthy thyroid tissues from PTC patients (HT-PTC). Total benign represents the sum of CG and FA cases. The p value refers to the positive association of the BRAF mutation with PTC, as compared to each diagnosis by Fisher’s exact test. Likewise, the odds ratio (OR) and 95% confidence interval (CI) were also calculated. NA = not applicable. The distribution of age () and gender () among diagnostic groups displayed no significant differences.