Research Article
A Bioinformatic Profile of Gene Expression of Colorectal Carcinoma Derived Organoids
Table 1
Gene ontology (GO) enrichment analysis of differentially expressed genes (DEG) in tumor organoids. Genes’ enrichment of biological processes (BP). EMT: Epithelial-mesenchymal transition; ECM: Extracellular matrix.
| | Category | Group | Term | GenesCount | GenesCount ratio of Total genes | P-Value | Benjamini |
| | GOTERM_BP_ALL | Upregulated | Population | Cell cycle (GO:0051726) | 10 | 10 | 4.80E-02 | 3.20E-01 | | Cell proliferation (GO:0042127) | 20 | 20 | 1.40E-04 | 4.80E-03 | | Growth (GO:0040007) | 16 | 16 | 3.90E-05 | 2.10E-03 | | Metastasis | Cell migration (GO:0016477) | 15 | 15 | 1.70E-03 | 2.90E-02 | | Cell motility (GO:0048870) | 16 | 16 | 1.80E-03 | 3.00E-02 | | Locomation (GO:0040011) | 17 | 17 | 2.70E-03 | 4.00E-02 | | EMT (GO:0001837) | 8 | 8 | 7.40E-07 | 2.00E-04 | | Cell adhesion (GO:0007155) | 15 | 15 | 3.50E-02 | 2.70E-01 | | Agiogenesis | Agiogenesis (GO:0001525) | 8 | 8 | 4.00E-03 | 5.50E-02 | | Vasculogenesis (GO:0001570) | 4 | 4 | 5.10E-03 | 6.40E-02 | | Others | Biosynthetic process (GO:0009889) | 37 | 37 | 2.90E-04 | 7.90E-03 | | Downregulated | Metastasis | Cell migration (GO:0016477) | 34 | 11.5 | 2.70E-04 | 1.70E-02 | | Cell motility (GO:0048870) | 36 | 12.2 | 5.10E-04 | 2.50E-02 | | Locomotion (GO:0040011) | 39 | 13.2 | 8.70E-04 | 3.50E-02 | | Localization of cell (GO:0051674) | 36 | 12.2 | 5.10E-04 | 2.50E-02 | | Cell adhesion; GO:0007155 | 37 | 12.5 | 1.50E-02 | 2.10E-01 | | Evading Cell death | Cell death (GO:0008219) | 49 | 16.6 | 2.20E-04 | 1.50E-02 | | Apoptosis (GO:0006915) | 44 | 14.9 | 4.60E-04 | 2.30E-02 | | Population | Growth (GO:0040007) | 27 | 9.1 | 1.30E-03 | 4.30E-02 | | Cell proliferation (GO:0008283) | 42 | 14.2 | 5.00E-03 | 1.00E-01 | | Inflammatory response | Chronic inflammatory response (GO:0002544) | 3 | 1 | 4.10E-02 | 3.60E-01 | | Inflammatory response (GO:0006954) | 19 | 6.4 | 6.10E-03 | 1.20E-01 | | Agiogenesis | Agiogenesis (GO:0001525) | 12 | 4.1 | 4.10E-02 | 3.60E-01 | | Others | ECM orgnazation (GO:0030198) | 20 | 6.8 | 5.10E-07 | 2.20E-03 | | Homeostatic process (GO:0042592) | 35 | 11.8 | 2.50E-02 | 2.80E-01 | | Secretion (GO:0046903) | 33 | 11.1 | 1.50E-04 | 1.20E-02 | | Immune system process (GO:0002376) | 50 | 16.9 | 1.50E-02 | 2.10E-01 |
|
|
