Research Article

A Bioinformatic Profile of Gene Expression of Colorectal Carcinoma Derived Organoids

Table 2

Gene ontology (GO) enrichment analysis of differentially expressed genes (DEGs) in tumor organoids. Genes’ enrichment of cell component (CC).

CategoryGroupTerm (GO)GenesCountP-Value

GOTERM_CC_ALLUpregulatedPlasma membrane part (GO:0044459)21212.20E-02
DownregulatedExtracellular region part (GO:0044421)11137.51.90E-13
Extracellular region (GO:0005576)12040.51.00E-11
Extracellular space (GO:0005615)5217.64.00E-09
Extracellular exosome (GO:0070062)7625.71.10E-07
Vesicle (GO:0031982)9331.41.20E-07
Extracellular vesicle (GO:1903561)7625.71.30E-07
Extracellular organelle (GO:0043230)7625.71.40E-07
Proteinaceous extracellular matrix (GO:0005578)217.14.50E-07
Extracellular matrix component (GO:0044420)124.13.10E-06
Extracellular matrix (GO:0031012)248.14.20E-06
Cell periphery (GO:0071944)11137.51.40E-05
Plasma membrane (GO:0005886)10836.52.50E-05
Plasma membrane part (GO:0044459)65222.90E-05
Plasma membrane region (GO:0098590)3110.55.60E-05
Basement membrane (GO:0005604)938.10E-05
Microvillus (GO:0005902)82.71.10E-04
Cell surface (GO:0009986)268.81.80E-04
Intrinsic component of plasma membrane (GO:0031226)4314.56.30E-04
Apical part of cell (GO:0045177)155.11.00E-03
Integral component of plasma membrane (GO:0005887)4113.91.00E-03
Membrane part (GO:0044425)13043.91.20E-03
Actin-based cell projection (GO:0098858)103.41.40E-03
Intrinsic component of membrane (GO:0031224)11338.21.40E-03
Apical plasma membrane (GO:0016324)134.41.40E-03
Anchored component of membrane (GO:0031225)932.30E-03
Integral component of membrane (GO:0016021)11037.22.40E-03
Membrane raft (GO:0045121)124.12.80E-03
Membrane microdomain (GO:0098857)124.12.90E-03
Brush border (GO:0005903)72.44.00E-03
Cluster of actin-based cell projections (GO:0098862)82.75.40E-03
Membrane region (GO:0098589)134.46.60E-03
Endomembrane system (GO:0012505)7525.38.70E-03
Basolateral plasma membrane (GO:0016323)931.10E-02
Membrane (GO:0016020)15853.41.90E-02
Caveola (GO:0005901)51.72.30E-02
Microvillus membrane (GO:0031528)313.10E-02
Plasma membrane raft (GO:0044853)51.73.30E-02
Cytoplasmic vesicle (GO:0031410)289.54.00E-02
Intracellular vesicle (GO:0097708)289.54.10E-02
Spanning component of membrane (GO:0089717)20.74.40E-02
Spanning component of plasma membrane (GO:0044214)20.74.40E-02
Actin cytoskeleton (GO:0015629)134.44.50E-02
Cytoplasmic, membrane-bounded vesicle (GO:0031410)268.84.50E-02