Effect of Chronic Kidney Disease on Changes in Vasopressin System Expression in the Kidney Cortex in Rats with Nephrectomy

Table 2

Biochemical parameters in the plasma.

Parameters	CN	N1/2	N2/3	N5/6
	(n=7)	(n=7)	(n=6)	(n=8)
osmolarity (mOsmol/kgH2O)	300 ± 2.9	338 ± 13.3	351 ± 7.9	335 ± 7.5
urea (mg/ml)	32.3 ± 1.3	44.6 ± 2.3	67.1 ± 5.3	75.3 ± 3.6
sodium (mmol/l)	140.6 ± 0.8	130.0 ± 1.0	138.5 ± 2.7	123.7 ± 16.8
creatinine (mg/dl)	0.3 ± 0.0	0.6 ± 0.0	0.7 ± 0.1	9.2 ± 8.4
eGFR (ml/min)	2.3 ± 0.2	1.6 ± 0.1^###	1.5 ± 0.2^&&	0.6 ± 0.1
cystatin C (pg/ml)	2992.4 ± 131.2	3477.9 ± 314.0	4360.2 ± 344.6	5708.9 ± 345.4
NT-proBNP (pg/ml)	131.2 ±17.5	288.5 ± 143.7	259.3 ± 97.1	378.9 ± 71.4

Biochemical parameters evaluated in the plasma. CN: control group; N1/2: 1/2 nephrectomy group; N2/3:2/3 nephrectomy group; N5/6: 5/6 nephrectomy group; eGFR: estimated glomerular filtration rate; NT-proBNP: N-terminal brain natriuretic peptide. Means ± SE are shown. Significant difference between N5/6 and CN groups; ^#significant difference between N5/6 and N1/2 groups; ^&significant difference between N5/6 and N2/3 groups; significant difference between N2/3 and CN groups; significant difference between N1/2 and CN groups. P<0.05; P<0.001; ^##P<0.01; ^###P<0.001; ^&&P<0.01; P<0.05; P<0.01; P<0.01.