Acetylation of HMGB1 by JNK1 Signaling Promotes LPS-Induced Peritoneal Mesothelial Cells Apoptosis
HAT inhibitor curcumin reduces the level of BAX and cleaved-caspase3 in LPS-stimulated HMrSV5 cells. (a) HAT activity in control and LPS-stimulated HMrSV5 cells was assessed by a Colorimetric Assay Kit as described in the Methods. Data are means±SE (n=3). p<0.05 versus control group. (b) HDAC activity among different groups. Data are means±SE (n=3). (c) The effect of curcumin on HAT activity in LPS-treated HMrSV5 cells. Data are means±SE (n=3). p<0.05 versus control group; †p<0.05 versus cells with LPS-treated alone. (d) Expression levels of indicated proteins were determined by immunoblotting analysis.
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.