The Immunoexpression of YAP1 and LATS1 Proteins in Clear Cell Renal Cell Carcinoma: Impact on Patients’ Survival

Figure 1

Evaluation of Yes-associated protein 1 (YAP1) and serine/threonine-protein kinase 1 (LATS1) expression levels in the sections of clear cell renal cell carcinoma (ccRCC) and unchanged kidney tissues by immunohistochemistry. In unchanged kidney cortex (a) strong YAP1 immunoreactivity was localized mainly in the cytoplasm of epithelial cells of proximal convoluted tubules (PCT). In ccRCC tumor cells YAP1 was expressed mainly in cell nuclei ((b) insert); however, weak to moderate YAP1 immunoreactivity was also observed in the cytoplasm of tumor cells in 13/54 ccRCC patients (b). Strong LATS1 immunoreactivity was present in the cytoplasm of PCT epithelium (c) and weak immunoreactivity in the cytoplasm of ccRCC cells (d), respectively. Magnifications: (a)–(d) ×200; insert (b) ×300.

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