The Immunoexpression of YAP1 and LATS1 Proteins in Clear Cell Renal Cell Carcinoma: Impact on Patients’ Survival

Table 3

Uni- and multivariate analysis (Cox proportional hazards regression) of overall survival of patients with clear cell renal cell carcinoma.

Parameter	Univariate Cox regression		Multivariate Cox regression
	HR (95% CI)	value	HR (95% CI)	value
YAP1 nuclear; immunoreactivity	0.63 (0.38–1.02)	0.0625
YAP1 cytoplasmic; immunoreactivity	3.24 (1.49–7.03)	0.0029	4.53 (1.73–11.9)	0.0022
LATS1 cytoplasmic; immunoreactivity	0.90 (0.81–0.99)	0.0255	0.90 (0.91–0.99)	0.0289
Gender; (women versus men)	0.97 (0.39–2.42)	0.9525
Age; (years)	1.02 (0.97–1.07)	0.3958
Tumor size; (cm)	1.17 (1.03–1.34)	0.0168	1.12 (0.93–1.36)	0.2231
Depth of invasion; (T3 versus T1 + T2)	2.03 (0.77–5.37)	0.1526
Fuhrman grade; (G3 versus G1 + G2)	4.07 (1.60–10.4)	0.0033	1.49 (0.56–3.97)	0.4299
Distant metastases; (M1 versus M0)	4.35 (1.64–11.5)	0.0032	4.94 (1.59–15.3)	0.0056

Median follow-up time: 40.6 months; HR: hazard ratio; CI: confidence interval; RQ: relative quantification. Significant values (<0.05) are given in bold.