Fractional Flow Reserve Derived from Coronary Computed Tomography Angiography Datasets: The Next Frontier in Noninvasive Assessment of Coronary Artery Disease
Table 1
Summary of presented clinical trials.
Trial
Study Population
n
Intervention
Findings
NXT
Stable CAD scheduled to undergo invasive angiography
251
CCTA vs
had higher diagnostic accuracy than CCTA
PLATFORM
New stable CAD
584
Noninvasive stress testing vs and ICA vs prior to ICA
In patients randomized to an early invasive coronary angiogram for stable CAD, was associated with a lower rate of angiography showing no obstructive CAD and safe cancellation of ICA.
RIPCORD
Stable chest pain
200
CTA vs
data resulted in a change in management in 36% of cases.
ADVANCE
Stable CAD
1000
CCTA Findings Reviewed
CCTA stenosis severity, importantly, even for mild CCTA stenosis, in addition to diabetes and hypertension were predictive of abnormal .
Functional Syntax Score
Stable multivessel disease
77
Noninvasive vs invasive anatomic and functional SYNTAX score.
Functional SYNTAX score utilizing yielded similar results to those obtained invasively and reclassified 30% of patients from the high- and intermediate- SYNTAX score to the low-risk tertile. has good accuracy in detecting functionally significant lesions in patients with multivessel disease.
