Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis

Table 1

Characteristics of included studies.

Author	Year	Setting	Study Design	n	Population	Mean Age	Male	Mean BMI	DM		HT	DLP	Smoke	Mean NLR
Coronary artery disease
Sonmez [10]	2013	Turkey	Cross-sectional	175	general	59.2	59.0	29.8	40.6		53.7	43.4	-	2.29
Naz [11]	2014	India	Case control	60	general	45	100	-	0		-	-	0	2.98
Mayyas [12]	2014	Jordan	Cross-sectional	128	general	57.4	57.0	29.6	44.5		77.3	62.5	35.2	2.67
Sari [13]	2015	Turkey	Cross-sectional	180	general	59.1	63.3	-	24.4		-	19.4	41.1	3.03
Aygün [14]	2015	Turkey	Cross-sectional	292	DM	56.3	88.4	-	100		64	55.5	33.2	2.00
Acar [15]	2015	Turkey	Cross-sectional	238	general	54.8	55.0	27.4	18.5		62.2	68.2	37.4	2.11
Verdoia [16]	2015	Italy	Cross-sectional	1,372	DM	69.0	69.2	28.3	100		80.9	60.3	22.9	-
Gungoren [17]	2015	Turkey	Case control	311	general	62.6	56.3	-	30.5		54.3	83.9	30.5	2.53
Yu [18]	2016	China	Cohort	942	general	64.9	58.7	24.4	36.2		68.3	13.2	37.6	2.92
Perl [19]	2016	Israel	Cross-sectional	522	general	66.0	73.0	-	36		72	80	43	3.21
Verdoia [20]	2016	Italy	Cross-sectional	3,728	general	67.6	69.3	-	36.8		71.2	55.4	26.6	-
Uysal [21]	2016	Turkey	Cross-sectional	194	general	62.5	69.0	-	26.3		29.4	12.4	38.7	2.59
Yilmaz [22]	2016	Turkey	Case control	80	general	59.5	52.5	-	14.4		22.5	-	17.5	2.51
Chittawar [23]	2017	India	Cross-sectional	265	DM	51.1	45.7	25.9	100		-	-	-	-
Guo [24]	2017	China	Cross-sectional	64	general	60.0	29.7	-	12.5		54.7	-	32.8	2.12
Sharma [25]	2017	India	Cross-sectional	324	general	-	-	-	-		-	-	-	1.31
Korkmaz [26]	2018	Turkey	Cross-sectional	113	general	57.0	78	-	-		-	-	-	2.41
Acute coronary syndrome
Yu [18]	2016	China	Cohort	600	general	64.9	58.7	24.4	36.2		68.3	13.2	37.6	3.33
Zazula [27]	2008	Brazil	Cross-sectional	178	general	60.0	59.0	-	28		78	44	17	4.32
Nordestgaard [28]	2010	Denmark	Case cohort	699	general	68.4	63.4	27.0	10.1		32.8	14.3	28.9	-
Caimi [29]	2015	Italy	Case control	239	general	34.9	83.3	-	-		-	-	-	2.10
Qiu [30]	2016	China	Case control	72	DM	64.1	58.3	25.2	100		-	-	45.8	5.39
Nalbant [31]	2016	Turkey	Cross-sectional	284	general	70.3	63.7	-	-		-	-	-	5.42
Göktaş [32]	2018	Turkey	Cross-sectional	100	general	57.8	50.0	-	-		-	-	-	-
Stroke
Saliba [33]	2015	Israel	Cohort	32,912	AF	73.2	48.4	-	32.8		74.7	59.2	-	-
Ertas [34]	2013	Turkey	Case control	126	AF	70.0	59.0	-	18.3		73	34.1	6.3	3.87
Celikbi-lek [35]	2014	Turkey	Case control	140	general	64.9	37.9	-	-		-	-	-	2.42
Akil [36]	2014	Turkey	Case control	85	general	52.3	58.8	25.0	-		5.9	-	23.5	2.38
Wang [37]	2015	China	Case control	100	general	57.4	53.0	-	-		-	-	-	1.74
Köklü [38]	2016	Turkey	Cross-sectional	254	general	69.5	70.5	26.0	42.5		76.8	68.5	31.5	2.62
Suh [39]	2017	South Korea	Cohort	24,708	general	51.8	49.9	-	17.9		22.1	26.9	18.3	-
Long [40]	2018	China	Cohort	210	Gastric cancer	67.1	72.9	-	-	-	-	-	-	4.24
Abete [41]	2018	Spain	Case control	102	general	60.1	64.7	30.6	18.6	57.8	39.2	54.9	-	2.15
Farah [42]	2018	Israel	Case control	230	general	68.4	59.0	-	-	-	-	-	-	3.24
Composite outcomes
Tsai [43]	2007	Taiwan	Cross-sectional	1,872	DM	60.1	44.4	25.5	100	-	-	20.5	-	-
Azab [44]	2013	US	Cohort	338	DM	58.1	36.1	-	100	77.2	77.2	29	-	-
Solak [45]	2013	Turkey	Cohort	225	CKD	50.4	47.6	25.8	22.2	14.2	-	44	-	3.31
Abe [46]	2015	Japan	Cohort	86	ESRD	58.0	67.4	22.0	48.8	62.8	30.2	18.6	-	-
Quiros-Roldan [47]	2016	Italy	Cohort	3,454	HIV	38.1	71.3	-	7.4	7.9	34.7	65.6	-	1.80

AF, atrial fibrillation; BMI, body mass index; CKD, chronic kidney disease; DLP, dyslipidemia; DM, diabetes mellitus; ESRD, end stage renal disease; HIV, human immunodeficiency virus; HT, hypertension; NLR, neutrophil lymphocyte ratio.