Review Article

Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis

Table 3

Mean difference of neutrophil lymphocyte ratio between CVD and non-CVD patients.

AuthorYearCVDNon-CVDMean differences
(95% CI)
Nmean [48]Nmean [48]

Coronary artery disease

Sonmez [10]20131062.37 (0.89)692.03 (1.56)0.34 (-0.07, 0.75)
Naz [11]2014403.67 (1.62)201.61 (0.84)2.06 (1.44, 2.68)
Mayyas [12]2014602.61 (0.17)682.72 (0.19)-0.11 (-0.17, -0.05)
Sari [13]20151003.70 (2.60)802.2 (1.7)1.50 (0.87, 2.13)
Acar [15]2015712.50 (0.70)901.90 (0.70)0.60 (0.38, 0.82)
Gungoren [17]20152612.73 (1.07)501.51 (0.42)1.22 (1.05, 1.39)
Yu [18]20166913.62 (2.70)2512.14 (1.97)1.48 (1.16, 1.79)
Perl [19]20161703.44 (2.90)3523.00 (2.50)0.44 (-0.16, 1.04)
Uysal [21]20161522.77 (0.23)421.97 (0.15)0.80 (0.74, 0.86)
Yilmaz [22]2016402.51(0.65)401.73 (0.71)0.78 (0.48, 1.08)
Guo [24]2017312.93(1.82)332.11 (0.79)0.82 (0.13, 1.52)
Sharma [25]
20172255.60(4.50)994.30 (3.80)1.30 (0.35, 2.25)
Korkmaz [26]2018632.66(0.86)502.10 (0.53)0.56 (0.30, 0.82)

USMD (95%CI)0.87 (0.52, 1.22)

Acute coronary syndrome

Yu [18]20163494.93 (3.15)2512.14 (1.97)2.79 (2.38, 3.20)
Nordestgaard [28]20081334.77 (3.83)453.00 (1.60)1.77 (0.97, 2.57)
Caimi [29]20151232.38 (0.87)1161.82 (0.71)0.56 (0.36, 0.76)
Qiu [30]2016388.10 (6.44)342.37 (1.19)5.73 (3.64, 7.82)
Nalbant [31]20161895.58 (6.60)955.10 (7.60)0.48 (-1.32, 2.28)

USMD (95%CI)2.12 (0.70, 3.53)

Stroke

Ertas [34]2013395.60 (3.40)873.10 (2.10)2.50 (1.35, 3.66)
Celikbilek [35]2014702.97 (0.53)701.88 (0.40)1.09 (0.96, 1.23)
Akil [36]2014383.10 (2.00)471.80 (0.40)1.30 (0.65, 1.95)
Wang [37]2015501.40 (0.83)501.40 (0.41)0.00 (-0.26, 0.26)
Köklü [38]20161153.09 (0.23)1392.23 (0.15)0.86 (0.81, 0.91)
Long [40]2018705.51 (8.02)1403.60 (1.89)1.91 (0.01, 3.82)
Abete [41]2018512.30 (0.50)512.00 (0.30)0.30 (0.14, 0.46)
Farah [42]20182003.44 (2.56)301.89 (0.61)1.55 (1.13, 1.97)

USMD (95% CI)0.92 (0.60, 1.24)

CI, confidence interval; CVD, cardiovascular disease; USMD, unstandardized mean difference.