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BioMed Research International
Volume 2018 (2018), Article ID 2739014, 9 pages
Review Article

The Relationship between Serum Zinc Level and Heart Failure: A Meta-Analysis

1Department of Cardiology, Tianjin Medical University General Hospital, Tianjin 300070, China
2Department of Cardiology, Tianjin Union Medical Center, Tianjin 300121, China

Correspondence should be addressed to Bo Bian; moc.361@yyzobnaib

Received 8 November 2017; Revised 15 January 2018; Accepted 24 January 2018; Published 25 February 2018

Academic Editor: Swaran J. S. Flora

Copyright © 2018 Xuefang Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Zinc is essential for the maintenance of normal cellular structure and functions. Zinc dyshomeostasis can lead to many diseases, such as cardiovascular disease. However, there are conflicting reports on the relationship between serum zinc levels and heart failure (HF). The purpose of the present study is to explore the relationship between serum zinc levels and HF by using a meta-analysis approach. PubMed, Web of Science, and OVID databases were searched for reports on the association between serum zinc levels and HF until June 2016. 12 reports with 1453 subjects from 27 case-control studies were chosen for the meta-analysis. Overall, the pooled analysis indicated that patients with HF had lower zinc levels than the control subjects. Further subgroup analysis stratified by different geographic locations also showed that HF patients had lower zinc levels than the control subjects. In addition, subgroup analysis stratified by HF subgroups found that patients with idiopathic dilated cardiomyopathy (IDCM) had lower zinc levels than the control subjects, except for patients with ischemic cardiomyopathy (ICM). In conclusion, the results of the meta-analysis indicate that there is a significant association between low serum zinc levels and HF.