Exosomes in the Oncobiology, Diagnosis, and Therapy of Hepatic Carcinoma: A New Player of an Old Game

Table 1

Exosome-mediated cellular interaction involved in liver cancer.

Donor cells	Components	Recipient cells	Functions	References
HKCI-C3; HKCI-8; MHCC-97L	MET proto-oncogene,; caveolins,; S100 family	MIHA	Migration, invasion	[13]
Huh7	miR-122	HepG2	Proliferation	[14]
HepG2	VASN	HUVECs	Migration	[15]
CD90+ Huh7	lncRNA H19	HUVECs	Angiogenesis, adhesion	[16]
CAFs	miR-320a	MHCC97-H	Proliferation, migration, metastasis	[17]
CSQT-2; HCC-LM3	miR-1247-3p	Normal fibroblasts	Conversion into CAFs	[18]
LX-2	miR-335	MHCC97H, MHCC97L, HepG2 and Huh7	Proliferation, invasion, tumor; shrinkage	[19]
Hepa1-6	α-AFP,; glypican 3,; HSP 70	DCs	T cell activation	[20]
Gastric cancer	EGFR	Kupffer cells; HSCs	Liver metastasis	[21]
Pancreatic ductal adenocarcinoma	MIF	Kupffer cells; HSCs	Liver metastasis	[22]
Breast cancer	integrin αvβ5	Kupffer cells	Liver metastasis	[23]
Colorectal cancer	miR-203	M2-TAMs	Liver metastasis	[24]
MHCC-97H	HGF	SMCC-7721	Chemoresistance	[25]
HepG2	linc-ROR	HepG2	Chemoresistance	[26]
HepG2	linc-VLDLR	HepG2	Chemoresistance	[27]
ADMSCs	miR-122	HepG2	Sorafenib sensistivity	[28]

ADMSCs: adipose-derived mesenchymal stem cells; CAFs: cancer associated fibroblasts; DCs: dendritic cells; HSCs: hepatic stellate cells; HUVECs: human umbilical vein endothelial cells; H22: murine hepatocarcinoma cell line; LX-2: hepatic stellate cells line; MIF: macrophage migration inhibitory factor; MIHA: immortalized hepatocyte cell line; and TAMs: tumor-associated macrophages.