Identification of Key Genes and Pathways in Triple-Negative Breast Cancer by Integrated Bioinformatics Analysis

Table 2

Molecular function (GO) enrichment analysis result of differentially expressed genes (DEGs) with fold change ≥1.5 or ≤-1.5 and p<0.01.

#pathway ID	pathway description	observed gene count	false discovery rate
GO.0000977	RNA polymerase II regulatory region sequence-specific DNA binding	16	0.001
GO.0044212	transcription regulatory region DNA binding	19	0.001
GO.0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	12	0.00502
GO.0000982	transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding	12	0.00599
GO.0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	10	0.00714
GO.0000976	transcription regulatory region sequence-specific DNA binding	15	0.00808
GO.0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	14	0.0459
GO.0000987	core promoter proximal region sequence-specific DNA binding	10	0.0459
GO.0001158	enhancer sequence-specific DNA binding	5	0.0459