C-Type Natriuretic Peptide Ameliorates Lipopolysaccharide-Induced Cardiac Dysfunction in Rats with Pulmonary Arterial Hypertension
Table 2
Effects of LPS on hemodynamics and left ventricle function.
Parameters
C group
C + LPS group
PAH group
PAH + LPS group
HR (bpm)
405.09 ± 20.89
398.93 ± 18.3
312.83 ± 31.28
285.64 ± 4.94
ESP (mmHg)
119.55 ± 10.14
120.78 ± 8.01
105.55 ± 16.15
85.93 ± 10.1
EDP (mmHg)
3.22 ± 2.61
1.1 ± 2.55
0.84 ± 2.17
3.69 ± 0.33
ESV (mL)
44.72 ± 12.62
48.46 ± 16.81
134.64 ± 45.03
81.49 ± 6.67
EDV (mL)
139.69 ± 18.85
139.69 ± 18.85
215.45 ± 63.13
106.08 ± 3.58
CO (mL)
43.14 ± 5.01
43.33 ± 6.41
26.48 ± 7.33
9.93 ± 1.23
EF (%)
75.73 ± 9.2
74.48 ± 9.03
39.9 ± 9.52
33.3 ± 4.77
dP/ (mmHg/s)
11508.2 ± 4000.4
11800.3 ± 3345.6
9183.1 ± 1456.6
6439.7 ± 930.2
-dP/ (mmHg/s)
10137.2 ± 1170.9
10220.1 ± 1603.1
7371.4 ± 1700.6
6320.3 ± 880.0
SW (mmHg × mL)
12106.0 ± 1900.5
12376.0 ± 2396.5
7901.4 ± 2360.5
2553.2 ± 202.3
Tau (ms)
8.13 ± 0.87
7.98 ± 0.68
10.29 ± 0.96
11.86 ± 0.43
Values are presented as mean ± SD, n = 10 in each group. C group: control group; HR: heart rate (beats/min); ESP: end systolic pressure; EDP: end diastolic pressure; ESV: end systolic volume; EDV: end diastolic volume; CO: cardiac output (mL/min); EF: ejection fraction (%); dP/: maximum rate of rise of LV pressure (mmHg/s); -dP/: minimum rate of rise of LV pressure (mmHg/s); SW: stroke work (mmHg × mL); Tau: time constant of relaxation (ms). P < 0.05: when compared with PAH group. P < 0.01: when compared with PAH group.
