C-Type Natriuretic Peptide Ameliorates Lipopolysaccharide-Induced Cardiac Dysfunction in Rats with Pulmonary Arterial Hypertension
Table 3
Hemodynamic parameters and the indices of LV function.
Parameters
Group
T0
T1
T2
HR (bpm)
P1
353.46 ± 18.5
339.74 ± 21.24
308.82 ± 32.94
P2
364.7 ± 23.27
318.13 ± 11.63#
285.64 ± 4.94#
P3
349.78 ± 12.84
316.71 ± 12.90#
328.19 ± 29.91#$
ESP (mmHg)
P1
117.63 ± 15.57
108.3 ± 12.36
105.55 ± 16.15
P2
124.75 ± 5.96
95.24 ± 6.29#
85.93 ± 10.1#
P3
123.03 ± 7.12
106.43 ± 16.31#
105.90 ± 15.14$
EDV (μL)
P1
203.49 ± 92.09
259.44 ± 79.5
219.03 ± 60.86
P2
190.74 ± 85.14
115.08 ± 9.68#
106.08 ± 3.58#
P3
266.06 ± 100.41
131.29 ± 26.81#
187.92 ± 68.02$
SV (L)
P1
100.9 ± 23.75
110.44 ± 27.71
93.39 ± 31.63
P2
99.7 ± 23.75
71.34 ± 35.74#
34.75 ± 4.16#
P3
111.72 ± 18.54
55.47 ± 7.93#
83.12 ± 28.63$
CO (mL)
P1
35.78 ± 8.82
33.74 ± 6.95
28.01 ± 7.21
P2
37.38 ± 6.76
17.10 ± 1.97#
9.93 ± 1.23#
P3
27.92 ± 1.19
17.53 ± 2.45#
39.06 ± 6.41$
EF (%)
P1
60.46 ± 15.44
54.82 ± 3.65
43.74 ± 9.76
P2
61.67 ± 13.93
44.38 ± 4.45#
33.3 ± 4.77#
P3
57.88 ± 16.32
42.54 ± 4.31#
46.61 ± 4.48$
dP/
P1
10072.6 ± 1131.9
9458.3 ± 1210.7
9183.1 ± 1456.5
P2
10922.6 ± 3081.6
7808.7 ± 1188.0#
6439.7 ± 930.2#
P3
10567.2 ± 1013.5
8612.1 ± 1972.4#
8839.8 ± 1674.1$
SW
P1
11153.1 ± 2472.0
10245. 0 ± 2913.3
12119.7 ± 2288.4
P2
9935.1 ± 2301.56
5445.4 ± 2853.2#
5299.7 ± 1397.82#
P3
12119.7 ± 2288.4
5299.7 ± 1397.8#
7829.7 ± 2916.2$
Tau
P1
9.16 ± 1.34
9.81 ± 1.1
10.43 ± 0.38
P2
9.24 ± 1.49
10.78 ± 0.84#
11.86 ± 0.43#
P3
9.15 ± 1.31
10.21 ± 0.58#
8.8 ± 1.31#$
Values were presented as mean ± standard deviation. Group P1: PAH rats treated with normal saline. Group P2: PAH rats treated with LPS. Group P3: PAH rats treated with LPS and CNP. T0: baseline parameters. T1: 1 hour after treatment with normal saline (P1) and LPS (P2, P3). T2: 1 hour after sequential treatment with normal saline (P1, P2) and CNP (P3). HR: heart rate (beats/min); ESP: end systolic pressure; EDV: end diastolic volume; SV: stroke volume (mL); CO: cardiac output (mL/min); EF: ejection fraction (%); dP/dt: rate of rise of LV pressure (mmHg/s); SW: stroke work (mmHg × ml); Tau: time constant of relaxation (ms). P < 0.05: compared with T0 in each group, #P < 0.05: compared with P1 at same time point and $P < 0.05: compared with P2 at same time point.
