Optimization of the Cytotoxic Activity of Three Streptomyces Strains Isolated from Guaviare River Sediments (Colombia, South America)

Table 1

Cytotoxic activity of forty Actinobacterial extracts against prostate (PC3), lung (A549), and breast (MDA-MB-231) cancer lines (Table 1). NA: non-activity. The results are expressed as an average ± standard deviation (n=3).

Strain	Cytotoxic Activity
	PC3	MDA-MB-231	A549
4	NA	NA	13.05±2.08
5	3.11±5.21	20.2±3.75	13.5±5.18
11	3.06±3.57	18.5±4.31	13.1±3.57
17	3.85±4.12	21.1±2.97	6.9±2.78
18	NA	16.11±5.26	1.5±2.35
20	24.24±2.78	NA	10±6.43
26	35.44±2.97	24.2±4.82	4.7±2.54
28	50.46±3.3	58.3±5.32	9.9±1.59
29	6.98±23.65	35.7±5.11	NA
30	18.78±2.26	NA	51.5±4.72
32	76.5±5.82	61±4.73	36.21±4.62
41	18.57±2.49	22.5±5.65	37.32±3.38
42	16.7±3.86	46.3±6.76	38.2±5.33
44	13.48±1.27	7.035±4.98	NA
48	15.6±5.42	5.05±3.97	NA
73	88.21 ± 3.85	64.94±1.96	75.69±2.42
83	NA	2.8±4.48	0.7±3.85
105	49.2±4.21	46.5±5.64	56.32±3.49
159	15.86±2.39	30.6±2.37	26.9±5.32
171	31.94±1.76	49.8±4.84	24.9±4.39
194	2.78±3.12	16±7.11	NA
239	30.41±6.72	57.1±3.16	10.5±4.61
245	5.74±3.21	27.1±5.96	NA
259	34.2±3.31	17.31±4.64	37.02±5.83
278	30.93±2.98	16.82±0.12	57.11±4.74
294	16.87±4.98	66.6±2.34	1.46±3.76
339	47.41±6.27	36.6±4.72	3.1±5.56
363	27.86±3.45	53.5±4.61	3.5±4.42
386	89.73±2.07	59.28±2.67	78.12±3.01
389	15.12±4.21	39.2±4.16	23±5.35
424	7.72±3.08	49.7±6.23	1.6±3.78
429	21.12±2.73	35.7±4.97	1.4±3.34
431	30.42±4.84	39.7±3.52	20.21±3.16
441	NA	NA	39.1±4.56
452	2.1±3.21	NA	0.8±3.42
461	NA	5.5±6.95	7±4.21
487	5.21±3.2	NA	13.4±5.67
491	11.12±4.37	20±1.01	9.31±3.98
519	85.12±4.76	62.17±4.36	84.71±2.86