HPV16-E6 Oncoprotein Activates TGF- and Wnt/-Catenin Pathways in the Epithelium-Mesenchymal Transition of Cataracts in a Transgenic Mouse Model

Figure 7

The MTA1 nuclear receptor increases its expression in K14E6 mice lens. (a) mRNA and protein expression of MTA1 evaluated by RT-qPCR or Western blot, respectively. (b) Immunohistochemistry detection of MTA1 protein in the lens of NT and K14E6 transgenic mice. As observed, the MTA1-positive nuclear signal in AE and TZ was higher in K14E6 transgenic mice lenses (Black arrows), as compared to NT lenses. Statistical significance: < 0.05 and < 0.001. Magnification: (b) (40x).

(a)

(b)