Pleurotus albidus Modulates Mitochondrial Metabolism Disrupted by Hyperglycaemia in EA.hy926 Endothelial Cells

Figure 4

Hypothetical mechanisms of action of Pleurotus albidus extract (PleExt) in EA.hy926 under high glucose. PleExt can activate Sirt 3, which helps normalize complex I activity and thus reduce ^• production. Therefore, the oxidative damage to lipids and proteins was also diminished. Ergothioneine, a key substrate for OCTN1, was found in PleExt and can be transported to intracellular compartments and modulate eNOS activity to normalize NO production.