Pleurotus albidus Modulates Mitochondrial Metabolism Disrupted by Hyperglycaemia in EA.hy926 Endothelial Cells
Table 2
Modulation of oxidative stress markers by Pleurotus albidus extract (PleExt) in EA.hy926 endothelial cell under hyperglycaemia.
Treatment
TBARS (nmol TMP/mg protein)
Carbonyl protein (nmol DNPH/mg protein)
SOD (U/mg protein)
CAT (U/mg protein)
NO (nmol nitrite/mg protein)
NG
0.18 ± 0.0
0.83 ± 0.0
179.33 ± 0.5
19.52 ± 2.7
0.37 ± 0.0
HG
0.35 ± 0.0
5.84 ± 0.3
134.43 ± 2.8
11.54 ± 1.4
0.11 ± 0.0
NG + PleExt 0.1 µg/mL
0.15 ± 0.0
0.63 ± 0.0
165.57 ± 5.0
21.47 ± 1.4
0.34 ± 0.0
NG + PleExt 0.5 µg/mL
0.12 ± 0.0
0.50 ± 0.0
172.20 ± 4.2
21.14 ± 4.2
0.35 ± 0.0
NG + PleExt 1.0 µg/mL
0.14 ± 0.0
0.40 ± 0.0
170.12 ± 1.5
20.56 ± 2.9
0.38 ± 0.0
HG + PleExt 0.1 µg/mL
0.31 ± 0.0
4.23 ± 0.5
123.71 ± 1.1
13.39 ± 1.0
0.36 ± 0.0
HG + PleExt 0.5 µg/mL
0.26 ± 0.0
2.08 ± 0.2
138.28 ± 0.1
15.62 ± 2.8
0.42 ± 0.0
HG + PleExt 1.0 µg/mL
0.17 ± 0.0
1.88 ± 0.0
160.48 ± 0.6
21.09 ± 2.0
0.35 ± 0.0
Content of oxidative stress markers in normal glucose (NG) or high glucose (HG) plus P. albidus extract (PleExt) after 5 days treatment. are expressed as mean ± SD of at least three independent experiments. Different letters indicate significantly different values among treatments according to the analysis of variance (ANOVA) and Tukey’s post hoc test. Statistical significance was determined at p < 0.05.
