Serum Metabolomics Analysis of Asthma in Different Inflammatory Phenotypes: A Cross-Sectional Study in Northeast China

Figure 2

OPLS-DA score plots and permutation tests results. The OPLS-DA discrimination and permutation tests between different groups: (a & e) EA versus NEA in ESI⁺, P = 0.0012; (b & f) EA versus HC in ESI⁺, P < 0.0001; (c & g) NEA versus HC in ESI⁺, P = 0.0002; (d & h) Asthma versus HC in ESI⁺, P < 0.0001; (i & m) EA versus NEA in ESI^-, P > 0.05; (j & n) EA versus HC in ESI^-, P < 0.0001; (k & o) NEA versus HC in ESI^-, P < 0.0001; (l & p) Asthma versus HC in ESI^-, P < 0.0001. EA was abbreviated as E, NEA as N, and HC as H. All P values were estimated with CV-ANOVA test. Ellipse in the OPLS-DA panels represents Hotelling’s T2 test with the confidence interval of 0.95.