Serum Metabolomics Analysis of Asthma in Different Inflammatory Phenotypes: A Cross-Sectional Study in Northeast China

Table 1

Characteristics of all subjects.

	Eosinophilic Asthma (EA)	Non-eosinophilic Asthma (NEA)	Healthy Control (HC)
Subjects Number	13	16	15
Gender (female/male)	5/8	9/7	6/9
Age/years	38.38 (33.00, 44.00)	40.75 (35.25, 47.5)	38.47 (31.5, 44.5)
BMI/(kg·m^-2)	24.09 (21.06, 26.21)	25.53 (21.56, 28.60)	22.99 (20.72, 25.81)
Serum IgE/(ng·mL^-1)	212.7 (134.9, 275.8)^∗∗#	102.6 (55.77, 132.1)	106.7 (76.00, 121.9)
ACQ6	0.9677 (0.67, 1.00)	1.074 (0.67, 1.35)	NA
FEV1/FVC ()	61.0 (54.0, 68.0)^∗∗	63.6 (56.8, 70.3)^∗∗	85.3 (82.5, 88.5)
FEV1/FVC (post)	77.8 (74.0, 81.0)	78.5 (74.3, 83.8)	NA
FEV1 Reversibility (mL)	333.8 (310.0, 380.0)	330.3 (285.0, 362.5)	NA
FEV1 Reversibility ()	16.8 (14.0, 19.0)	14.9 (12.8, 16.3)	NA
Eosinophil ()	8.5 (6.0, 10.0) ^∗∗##	1.3 (1.0, 2.0)	2.0 (1.0, 2.3)
Neutrophil ()	56.2 (50.0, 59.0)^#	64.8 (59.3, 70.3)	59.75 (56.5, 64.0)
Score1	20.46 (10.95, 19.82)^#	9.47 (8.23, 10.25)	NA
Score2	25.70 (11.71, 25.71)^#	6.37 (4.54, 6.26)	NA

are shown as mean (Q1, Q3). is the average of ACQ6 scores according to the GINA guidelines (updated in 2016)[15]. ^∗P < 0.05 versus healthy control group. ^∗∗P < 0.01 versus healthy control group. ^#P < 0.05 versus noneosinophilic asthma group. ^##P < 0.01 versus noneosinophilic asthma group.