Review Article

A Review of Selected Factors of Salivary Gland Tumour Formation and Malignant Transformation

Table 1

Histopathological classification of salivary gland tumours, according to WHO.

Epithelial tumours

MalignantBenign

(i) Acinic cell carcinoma(i) Pleomorphic adenoma (PA)
(ii) Mucoepidermoid carcinoma (MEC) (a) Metastasizing pleomorphic adenoma
(iii) Adenoid cystic carcinoma (ACC)(ii) Myoepithelioma
(iv) Polymorphous adenocarcinoma (PAC) (before 2017: Polymorphous low-grade adenocarcinoma – PLGA)(iii) Basal cell adenoma
(v) Epithelial-myoepithelial carcinoma (EMC)(iv) Warthin’s tumour
(vi) Clear cell carcinoma(v) Oncocytoma
(vii) Basal cell adenocarcinoma(vi) Canalicular adenoma
(viii) Sebaceous carcinoma(vii) Lymphadenoma
(ix) Intraductal carcinoma (a) Sebaceous lymphadenoma
 (a) Low-grade cribriform cystadenocarcinoma (b) Nonsebaceous lymphadenoma
 (b) Salivary duct carcinoma (c) Sebaceous lymph adenocarcinoma
 (c) Salivary duct carcinoma, not otherwise specified(viii) Ductal papilloma
(x) Oncocytic carcinoma (a) Inverted ductal papilloma
(xi) Adenocarcinoma, not otherwise specified (NOS) (b) Intraductal papilloma
 (a) Cystadenocarcinoma (c) Sialadenoma papilliferum
 (b) Mucinous adenocarcinoma(ix) Cystadenoma
(xii) Myoepithelial carcinoma
(xiii) Carcinoma ex pleomorphic adenoma (CXPA)
(xiv) Secretory carcinoma
(xv) Carcinosarcoma
(xvi) Squamous cell carcinoma
(xvii) Large cell carcinoma
(xviii) Lymphoepithelial carcinoma
(xix) Sialoblastoma

Other epithelial lesions

(i) Intercalated duct lesions
 (a) Intercalated duct adenoma
 (b) Intercalated duct hyperplasia (IDH)
(ii) Nodular oncocytic hyperplasia
(iii) Lymphoepithelial lesions

Soft tissue tumours

(i) Haemangioma
(ii) Lipoma
(iii) Nodular fasciitis

Haematolymphoid tumours

(i) Hodgkin lymphoma
(ii) Diffuse large B-cell lymphoma
(iii) Extranodal marginal zone B-cell lymphoma

Secondary tumours

(i) Tumours which have metastasized to the salivary gland from another location