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BioMed Research International
Volume 2018, Article ID 2925985, 9 pages
https://doi.org/10.1155/2018/2925985
Research Article

Regulation of Spontaneous Contractions in Intact Rat Bladder Strips and the Effects of Hydrogen Peroxide

1Department of Surgery, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA
2Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
3Division of Urogynecology, Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan
4Department of Urology, Shengjing Hospital, China Medical University, Shenyang, China

Correspondence should be addressed to Guiming Liu; ude.esac@uil.gnimiug

Received 23 August 2017; Revised 1 December 2017; Accepted 31 December 2017; Published 4 February 2018

Academic Editor: Kota V. Ramana

Copyright © 2018 Mingshuai Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. M. Levin, M. R. Ruggieri, S. Velagapudi, D. Gordon, B. Altman, and Wein. A. J., “Relevance of spontaneous activity to urinary bladder function: an in vitro and in vivo study,” The Journal of Urology, vol. 136, pp. 517–521, 1986. View at Google Scholar
  2. A. F. Brading, “A myogenic basis for the overactive bladder,” Urology, vol. 50, pp. 57–67, 1997. View at Google Scholar
  3. A. F. Brading, “Spontaneous activity of lower urinary tract smooth muscles: correlation between ion channels and tissue function,” The Journal of Physiology, vol. 570, no. 1, pp. 13–22, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. J. E. Speich, C. W. Wilson, A. M. Almasri, J. B. Southern, A. P. Klausner, and P. H. Ratz, “Carbachol-induced volume adaptation in mouse bladder and length adaptation via rhythmic contraction in rabbit detrusor,” Annals of Biomedical Engineering, vol. 40, no. 10, pp. 2266–2276, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. C. H. Fry, G.-P. Sui, N. J. Severs, and C. Wu, “Spontaneous activity and electrical coupling in human detrusor smooth muscle: Implications for detrusor overactivity?” Urology, vol. 63, no. 3, pp. 3–10, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. K.-E. Andersson, “Detrusor myocyte activity and afferent signaling,” Neurourology and Urodynamics, vol. 29, no. 1, pp. 97–106, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Hashitani, A. F. Brading, and H. Suzuki, “Correlation between spontaneous electrical, calcium and mechanical activity in detrusor smooth muscle of the guinea-pig bladder,” British Journal of Pharmacology, vol. 141, no. 1, pp. 183–193, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. G. V. Petkov, “Central role of the BK channel in urinary bladder smooth muscle physiology and pathophysiology,” American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, vol. 307, no. 6, pp. R571–R584, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. S. A. Y. Afeli, E. S. Rovner, and G. V. Petkov, “SK but not IK channels regulate human detrusor smooth muscle spontaneous and nerve-evoked contractions,” American Journal of Physiology-Renal Physiology, vol. 303, no. 4, pp. F559–F568, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. P. H. Ratz and A. S. Miner, “Length-dependent regulation of basal myosin phosphorylation and force in detrusor smooth muscle,” American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, vol. 284, no. 4, pp. R1063–R1070, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. J. A. Hypolite, Q. Lei, S. Chang et al., “Spontaneous and evoked contractions are regulated by PKC-mediated signaling in detrusor smooth muscle: Involvement of BK channels,” American Journal of Physiology-Renal Physiology, vol. 304, no. 5, pp. F451–F462, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. N. Xiao, Z. Wang, Y. Huang, F. Daneshgari, and G. Liu, “Roles of polyuria and hyperglycemia in bladder dysfunction in diabetes,” The Journal of Urology, vol. 189, no. 3, pp. 1130–1136, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. C. M. Callaghan, C. Schuler, R. E. Leggett, and R. M. Levin, “Effect of severity and duration of bladder outlet obstruction on catalase and superoxide dismutase activity,” International Journal of Urology, vol. 20, no. 11, pp. 1130–1135, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. Q. Zhang, M. Siroky, J.-H. Yang, Z. Zhao, and K. Azadzoi, “Effects of ischemia and oxidative stress on bladder purinoceptors expression,” Urology, vol. 84, no. 5, pp. 1249.e1–1249.e7, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. J.-H. Shin, G.-H. Kim, K.-H. Song, Y.-G. Na, C.-K. Sul, and J.-S. Lim, “Protective effect of N-acetylcysteine against ischemia/reperfusion injury in rat urinary bladders,” Cell Biochemistry & Function, vol. 32, no. 1, pp. 24–30, 2014. View at Publisher · View at Google Scholar · View at Scopus
  16. P. J. Gomez-Pinilla, M. F. Gomez, K. Swärd et al., “Melatonin restores impaired contractility in aged guinea pig urinary bladder,” Journal of Pineal Research, vol. 44, no. 4, pp. 416–425, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. Y.-B. Huang, M.-W. Lin, Y. Chao, C.-T. Huang, Y.-H. Tsai, and P.-C. Wu, “Anti-oxidant activity and attenuation of bladder hyperactivity by the flavonoid compound kaempferol,” International Journal of Urology, vol. 21, no. 1, pp. 94–98, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. H. Masuda, K. Kihara, K. Saito et al., “Reactive oxygen species mediate detrusor overactivity via sensitization of afferent pathway in the bladder of anaesthetized rats,” BJU International, vol. 101, no. 6, pp. 775–780, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. G. Liu, R. A. Elrashidy, N. Xiao et al., “Bladder function in mice with inducible smooth muscle-specific deletion of the manganese superoxide dismutase gene,” American Journal of Physiology-Cell Physiology, vol. 309, no. 3, pp. C169–C178, 2015. View at Publisher · View at Google Scholar · View at Scopus
  20. V. I. Lushchak, “Free radicals, reactive oxygen species, oxidative stress and its classification,” Chemico-Biological Interactions, vol. 224, pp. 164–175, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. P. D. Ray, B. Huang, and Y. Tsuji, “Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling,” Cellular Signalling, vol. 24, no. 5, pp. 981–990, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. K. Kiselyov and S. Muallem, “ROS and intracellular ion channels,” Cell Calcium, vol. 60, no. 2, pp. 108–114, 2016. View at Google Scholar
  23. K. M. Holmström and T. Finkel, “Cellular mechanisms and physiological consequences of redox-dependent signalling,” Nature Reviews Molecular Cell Biology, vol. 15, no. 6, pp. 411–421, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. L. Malone, C. Schuler, RE. Leggett, and R. M. Levin, “The effect of in vitro oxidative stress on the female rabbit bladder contractile response and antioxidant levels,” ISRN Urology, vol. 2013, Article ID 639685, 6 pages, 2013. View at Publisher · View at Google Scholar
  25. K. Kojima, H. Kume, S. Ito et al., “Direct effects of hydrogen peroxide on airway smooth muscle tone: Roles of Ca2+ influx and Rho-kinase,” European Journal of Pharmacology, vol. 556, no. 1-3, pp. 151–156, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. J. H. Han, M. Y. Lee, S. Y. Lee et al., “Effect of low concentrations of hydrogen peroxide on the contractile responses of rat detrusor smooth muscle strips,” European Journal of Pharmacology, vol. 638, no. 1-3, pp. 115–120, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. S. A. Buckner, I. Milicic, A. V. Daza, M. J. Coghlan, and M. Gopalakrishnan, “Spontaneous phasic activity of the pig urinary bladder smooth muscle: Characteristics and sensitivity to potassium channel modulators,” British Journal of Pharmacology, vol. 135, no. 3, pp. 639–648, 2002. View at Publisher · View at Google Scholar · View at Scopus
  28. L. A. Birder, M. Ruggieri, M. Takeda et al., “How does the urothelium affect bladder function in health and disease?: ICI-RS 2011,” Neurourology and Urodynamics, vol. 31, no. 3, pp. 293–299, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. G. Liu and F. Daneshgari, “Alterations in neurogenically mediated contractile responses of urinary bladder in rats with diabetes,” American Journal of Physiology-Renal Physiology, vol. 288, no. 6, pp. F1220–F1226, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. F. Daneshgari, G. Liu, and P. B. Imrey, “Time Dependent Changes in Diabetic Cystopathy in Rats Include Compensated and Decompensated Bladder Function,” The Journal of Urology, vol. 176, no. 1, pp. 380–386, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. G. M. Herrera, T. J. Heppner, and M. T. Nelson, “Regulation of urinary bladder smooth muscle contractions by ryanodine receptors and BK and SK channels,” American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, vol. 279, no. 1, pp. R60–R68, 2000. View at Publisher · View at Google Scholar
  32. T. Imai, T. Okamoto, Y. Yamamoto et al., “Effects of different types of K+ channel modulators on the spontaneous myogenic contraction of guinea-pig urinary bladder smooth muscle,” Acta Physiologica Scandinavica, vol. 173, no. 3, pp. 323–333, 2001. View at Publisher · View at Google Scholar · View at Scopus
  33. V. Y. Ganitkevich and G. Isenberg, “Contribution of Ca(2+)‐induced Ca2+ release to the [Ca2+]i transients in myocytes from guinea‐pig urinary bladder.,” The Journal of Physiology, vol. 458, no. 1, pp. 119–137, 1992. View at Publisher · View at Google Scholar · View at Scopus
  34. K. Aikawa, R. E. Leggett, and R. M. Levin, “Effect of age on hydrogen peroxide mediated contraction damage in the male rat bladder,” The Journal of Urology, vol. 170, no. 5, pp. 2082–2085, 2003. View at Publisher · View at Google Scholar · View at Scopus
  35. O. Z. Shenfeld, K. A. McCammon, P. F. Blackmore, and P. H. Ratz, “Rapid effects of estrogen and progesterone on tone and spontaneous rhythmic contractions of the rabbit bladder,” Urolithiasis, vol. 27, no. 5, pp. 386–392, 1999. View at Publisher · View at Google Scholar · View at Scopus
  36. L. Merrill and M. A. Vizzard, “Intravesical TRPV4 blockade reduces repeated variate stress-induced bladder dysfunction by increasing bladder capacity and decreasing voiding frequency in male rats,” American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, vol. 307, no. 4, pp. R471–R480, 2014. View at Publisher · View at Google Scholar · View at Scopus
  37. D. E. Artim, F. A. Kullmann, S. L. Daugherty, H.-Y. Wu, and W. C. De Groat, “Activation of the nitric oxide-cGMP pathway reduces phasic contractions in neonatal rat bladder strips via protein kinase G,” American Journal of Physiology-Renal Physiology, vol. 297, no. 2, pp. F333–F340, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. S. P. Parajuli, K. L. Hristov, R. P. Soder, W. F. Kellett, and G. V. Petkov, “NS309 decreases rat detrusor smooth muscle membrane potential and phasic contractions by activating SK3 channels,” British Journal of Pharmacology, vol. 168, no. 7, pp. 1611–1625, 2013. View at Publisher · View at Google Scholar · View at Scopus
  39. H. Akino, C. R. Chapple, N. McKay et al., “Spontaneous contractions of the pig urinary bladder: The effect of ATP-sensitive potassium channels and the role of the mucosa,” BJU International, vol. 102, no. 9, pp. 1168–1174, 2008. View at Publisher · View at Google Scholar · View at Scopus
  40. A. P. Somlyo and A. V. Somlyo, “Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II,” The Journal of Physiology, vol. 522, no. 2, pp. 177–185, 2000. View at Publisher · View at Google Scholar · View at Scopus
  41. A. Singh, M. E. Hildebrand, E. Garcia, and T. P. Snutch, “The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels,” British Journal of Pharmacology, vol. 160, no. 6, pp. 1464–1475, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. A. Kanai, J. Roppolo, Y. Ikeda et al., “Origin of spontaneous activity in neonatal and adult rat bladders and its enhancement by stretch and muscarinic agonists,” American Journal of Physiology-Renal Physiology, vol. 292, no. 3, pp. F1065–F1072, 2007. View at Publisher · View at Google Scholar · View at Scopus
  43. M. H. Hawthorn, C. R. Chapple, M. Cock, and R. Chess-Williams, “Urothelium-derived inhibitory factor(s) influences on detrusor muscle contractility in vitro,” British Journal of Pharmacology, vol. 129, no. 3, pp. 416–419, 2000. View at Publisher · View at Google Scholar · View at Scopus
  44. G. Meissner, “Ryanodine activation and inhibition of the Ca2+ release channel of sarcoplasmic reticulum,” The Journal of Biological Chemistry, vol. 261, no. 14, pp. 6300–6306, 1986. View at Google Scholar · View at Scopus
  45. S. Oger, D. Behr-Roussel, D. Gorny et al., “Effects of potassium channel modulators on myogenic spontaneous phasic contractile activity in human detrusor from neurogenic patients,” BJU International, vol. 108, no. 4, pp. 604–611, 2011. View at Publisher · View at Google Scholar · View at Scopus
  46. M. Kita, T. Yunoki, K. Takimoto et al., “Effects of bladder outlet obstruction on properties of Ca 2+-activated K+ channels in rat bladder,” American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, vol. 298, no. 5, pp. R1310–R1319, 2010. View at Publisher · View at Google Scholar · View at Scopus
  47. J. J. Layne, B. Nausch, S.-P. Olesen, and M. T. Nelson, “BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle,” American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, vol. 298, no. 2, pp. R378–R384, 2010. View at Publisher · View at Google Scholar · View at Scopus
  48. R. P. Soder and G. V. Petkov, “Large conductance Ca2+-activated K+ channel activation with NS1619 decreases myogenic and neurogenic contractions of rat detrusor smooth muscle,” European Journal of Pharmacology, vol. 670, no. 1, pp. 252–259, 2011. View at Publisher · View at Google Scholar · View at Scopus
  49. M. Li, Y. Sun, J. M. Simard, J.-Y. Wang, and T. C. Chai, “Augmented bladder urothelial polyamine signaling and block of BK channel in the pathophysiology of overactive bladder syndrome,” American Journal of Physiology-Cell Physiology, vol. 297, no. 6, pp. C1445–C1451, 2009. View at Publisher · View at Google Scholar · View at Scopus
  50. H. Zakoji, H. Kobayashi, M. Yoshiyama, M. Takeda, and I. Araki, “Expression of Large Conductance, Voltage- and Ca2+-Activated K+ (BK) Channels in Human Urinary Bladder: Alteration of Subunit Expression Profile in Association with Bladder Outlet Obstruction,” Open Journal of Urology, vol. 03, no. 02, pp. 47–52, 2013. View at Publisher · View at Google Scholar
  51. J. Singh and S. Rattan, “Role of PKC and RhoA/ROCK pathways in the spontaneous phasic activity in the rectal smooth muscle,” American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 304, no. 8, pp. G723–G731, 2013. View at Publisher · View at Google Scholar · View at Scopus
  52. G. A. Knock and J. P. T. Ward, “Redox regulation of protein kinases as a modulator of vascular function,” Antioxidants & Redox Signaling, vol. 15, no. 6, pp. 1531–1547, 2011. View at Publisher · View at Google Scholar · View at Scopus
  53. Y. Wei, Z. Wang, E. Babilonia, H. Sterling, P. Sun, and W. Wang, “Effect of hydrogen peroxide on ROMK channels in the cortical collecting duct,” American Journal of Physiology-Renal Physiology, vol. 292, no. 4, pp. F1151–F1156, 2007. View at Publisher · View at Google Scholar · View at Scopus
  54. O. Al-Shboul and A. Mustafa, “Effect of oxidative stress on Rho kinase II and smooth muscle contraction in rat stomach,” Canadian Journal of Physiology and Pharmacology, vol. 93, no. 6, pp. 405–411, 2015. View at Publisher · View at Google Scholar · View at Scopus
  55. A. B. García-Redondo, A. M. Briones, S. Martínez-Revelles et al., “C-Src, ERK1/2 and Rho kinasemediate hydrogen peroxide-induced vascular contraction in hypertension: Role ofTXA2, NAD(P)H oxidase andmitochondria,” Journal of Hypertension, vol. 33, no. 1, pp. 77–87, 2015. View at Publisher · View at Google Scholar · View at Scopus
  56. L. Jin, Z. Ying, and R. C. Webb, “Activation of Rho/Rho kinase signaling pathway by reactive oxygen species in rat aorta,” American Journal of Physiology-Heart and Circulatory Physiology, vol. 287, no. 4, pp. H1495–H1500, 2004. View at Publisher · View at Google Scholar · View at Scopus
  57. M. Nomiya, K. Sagawa, J. Yazaki et al., “Increased bladder activity is associated with elevated oxidative stress markers and proinflammatory cytokines in a rat model of atherosclerosis-induced chronic bladder ischemia,” Neurourology and Urodynamics, vol. 31, no. 1, pp. 185–189, 2012. View at Publisher · View at Google Scholar · View at Scopus