Regulation of Spontaneous Contractions in Intact Rat Bladder Strips and the Effects of Hydrogen Peroxide
Table 1
Effects of specific activators and blockers on spontaneous contractions in intact bladder strips (Phase 2 values as percentages of Phase 1 values).
Drugs (concentration)
Basal tension (%)
Amplitude (%)
Frequency (%)
Control (vehicle + H2O2)
13
86.4 ± 2.36
67.5 ± 5.09
103.4 ± 3.29
Nisoldipine (100 nM)
6
79.5 ± 4.86
67.8 ± 7.73
103.3 ± 3.41
SKF96365 (10 µM)
6
100.7 ± 7.31
Ryanodine (10 µM)
5
89.8 ± 8.20
82.4 ± 8.89
Iberiotoxin (100 nM)
8
106.8 ± 4.43
NS1619 (30 µM)
5
109.2 ± 5.97
Apamin (100 nM)
9
84.7 ± 5.64
NS309 (10 µM)
6
80.1 ± 2.20
BIS1 (2 µM)
7
81.0 ± 2.45
68.78 ± 4.97
118.4 ± 16.58
Y27632 (10 µM)
9
Y27632 (10 µM) + NS309 (10 µM)
5
Values are expressed as mean plus or minus SEM of 5 to 13 individual strips; significantly different from corresponding value in vehicle treated group ().
