Hepatitis C Virus-Infected Responders and Relapsers to Treatment Show Similar Genetic Profiles of IL28B and IL10 Single Nucleotide Polymorphisms
Table 2
Association between IL28B and IL10 SNPs and responders and nonresponders.
Genotype/haplotype
Responders
Nonresponders
OR (95% CI)
OR (95% CI)
rs12979860
TT
4 (0.16)
22 (0.36)
Reference
Reference
CT
9 (0.36)
28 (0.46)
0.57 (0.15–2.08) ()
0.46 (0.12–1.80) ()
CC
12 (0.48)
11 (0.18)
0.17 (0.04–0.64) ()
0.18 (0.04–0.76) ()
CC versus CT/TT
0.24 (0.09–0.66) ()
0.31 (0.11–0.90) ()
rs8099917
GG
4 (0.16)
18 (0.30)
Reference
Reference
GT
3 (0.12)
20 (0.33)
1.48 (0.29–7.54) ()
2.18 (0.40–11.93) ()
TT
18 (0.72)
23 (0.38)
0.28 (0.08–0.99) ()
0.42 (0.11–1.59) ()
TT versus GT/GG
0.23 (0.08–0.64) ()
0.29 (0.10–0.84) ()
rs1800872 (-592)
CC
7 (0.33)
20 (0.36)
Reference
CA
10 (0.48)
22 (0.39)
0.77 (0.25–2.41) ()
AA
4 (0.19)
14 (0.25)
1.22 (0.30–4.99) ()
CA/AA versus CC
0.9 (0.31–2.60) ()
rs1800871 (-819)
CC
6 (0.29)
20 (0.36)
Reference
CT
10 (0.48)
22 (0.39)
0.66 (0.20–2.14) ()
TT
5 (0.24)
14 (0.25)
0.84 (0.21–3.30) ()
CT/TT versus CC
0.72 (0.24–2.14) ()
rs1800896 (-1082)
AA
13 (0.62)
26 (0.46)
Reference
GA
8 (0.38)
24 (0.43)
0.67 (0.24–1.89) ()
GG
0
6 (0.11)
not done
GA/GG versus AA
1.88 (0.67–5.22) ()
rs12979860/rs8099917
T/G
0.13
0.31
Reference
C/G
0.09
0.15
0.69 (0.16–3.03) ()
C/T
0.57
0.26
0.27 (0.11–0.68) ()
T/T
0.21
0.28
0.68 (0.24–1.88) ()
OR: odds ratio; CI: confidence interval. Multivariate models including rs12979860 and rs8099917. Comparisons between crude (rs12979860) and multivariate model including rs12979860 and rs8099917 were statistically significant in codominant () and recessive models (). Haplotype frequencies were estimated by maximum likelihood.
