Research Article
Hepatitis C Virus-Infected Responders and Relapsers to Treatment Show Similar Genetic Profiles of IL28B and IL10 Single Nucleotide Polymorphisms
Table 4
Association between IL28B and IL10 SNPs and responders and relapsers.
| | Genotype/haplotype | Responders | Relapsers | OR (95% CI) |
| | rs12979860 | | | | | TT | 4 (0.16) | 8 (0.23) | Reference | | CT | 9 (0.36) | 11 (0.31) | 0.61 (0.13–2.71) () | | CC | 12 (0.48) | 16 (0.46) | 0.67 (0.16–2.74) () |
| | CC versus CT/TT | | | 0.91 (0.32–2.55) () |
| | rs8099917 | | | | | GG | 4 (0.16) | 6 (0.17) | Reference | | GT | 3 (0.12) | 7 (0.20) | 1.56 (0.24–9.91) () | | TT | 18 (0.72) | 22 (0.63) | 0.81 (0.20–3.34) () |
| | TT versus GT/GG | | | 0.66 (0.22–2.00) () |
| | rs1800872 (-592) | | | | | CC | 7 (0.33) | 10 (0.32) | Reference | | CA | 10 (0.48) | 16 (0.52) | 1.12 (0.32–3.90) () | | AA | 4 (0.19) | 5 (0.16) | 0.87 (0.17–4.47) () |
| | CA/AA versus CC | | | 1.05 (0.32–3.41) () |
| | rs1800871 (-819) | | | | | CC | 6 (0.29) | 9 (0.29) | Reference | | CT | 10 (0.48) | 17 (0.55) | 1.13 (0.31–4.13) () | | TT | 5 (0.24) | 5 (0.16) | 0.67 (0.13–3.34) () |
| | CT/TT versus CC | | | 0.98 (0.29–3.32) () |
| | rs1800896 (-1082) | | | | | AA | 13 (0.62) | 19 (0.61) | Reference | | GA | 8 (0.38) | 10 (0.32) | 0.85 (0.26–2.74) () | | GG | 0 | 2 (0.06) | Not done |
| | GA/GG versus AA | | | 1.02 (0.32–3.20) () |
| | rs12979860/rs8099917 | | | | | T/G | 0.13 | 0.18 | Reference | | C/G | 0.09 | 0.10 | 0.83 (0.18–3.88) () | | C/T | 0.57 | 0.52 | 0.76 (0.30–1.94) () | | T/T | 0.21 | 0.21 | 0.82 (0.27–2.54) () |
|
|
Haplotype frequencies were estimated by maximum likelihood. OR: odds ratio; CI: confidence interval.
|
